ReviewThe Journal of physiology2012
Inefficient functional sympatholysis is an overlooked cause of malperfusion in contracting skeletal muscle.
Review in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 116 citations in OpenAlex.
- L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women.Nutrients · 2024Trial
- Impaired modulation of postjunctional αThe Journal of physiology · 2018Trial
- Plasma Nucleotide Dynamics during Exercise and Recovery in Highly Trained Athletes and Recreationally Active Individuals.BioMed research international · 2018Trial
- Aging is associated with altered vasodilator kinetics in dynamically contracting muscle: role of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Differential effects of nebivolol versus metoprolol on functional sympatholysis in hypertensive humans.Hypertension (Dallas, Tex. : 1979) · 2013Trial
- Test-retest reliability of Doppler ultrasound-based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease.Experimental physiology · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Brachial blood flow and pressure responses are unrelated to the greater isometric handgrip tolerance of females compared to males.Physiological reports · 2026Article
- Endogenous muscarinic acetylcholine receptor signaling blunts αAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Functional sympatholysis of neuropeptide Y-mediated vasoconstriction in humans.The Journal of physiology · 2025Article
- Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement in young healthy males.Physiological reports · 2025Article
- Amygdala-hypothalamus-brainstem circuits underlying cardiovascular responses associated with the limits of high-intensity endurance exercise.Frontiers in physiology · 2025Review
- Endothelial and exercise vasodilation are reduced in postmenopausal females with obesity versus lean and overweight.International journal of obesity (2005) · 2024Article
- Hyperaemia during dynamic handgrip exercise is preserved in healthy young subjects after recovery from COVID-19.Experimental physiology · 2024Article
- Acute sympathetic activation blunts the hyperemic and vasodilatory response to passive leg movement.Research square · 2024Article
- Exercise for patients with chronic kidney disease: from cells to systems to function.American journal of physiology. Renal physiology · 2024Review
- Impact of ischemic preconditioning combined with aerobic exercise on 24-h ambulatory blood pressure in men with prehypertension and stage 1 hypertension.Frontiers in physiology · 2024Article
- Neural control of the circulation during exercise in heart failure with reduced and preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Review
- Clinical and Prognostic Value of Exaggerated Blood Pressure Response to Exercise.Reviews in cardiovascular medicine · 2023Review
- Sympathetic and hemodynamic responses to exercise in heart failure with preserved ejection fraction.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contracting skeletal muscle can overcome sympathetic vasoconstrictor activity (functional sympatholysis), which allows for a blood supply that matches the metabolic demand. This ability is thought to be mediated by locally released substances that modulate the effect of noradrenaline (NA) on the α-receptor. Tyramine induces local NA release and can be used in humans to investigate the underlying mechanisms and physiological importance of functional sympatholysis in the muscles of healthy and diseased individuals as well as the impact of the active muscles' training status. In sedentary elderly men, functional sympatholysis and muscle blood flow are impaired compared to young men, but regular physical activity can prevent these age related impairments. In young subjects, two weeks of leg immobilization causes a reduced ability for functional sympatholysis, whereas the trained leg maintained this function. Patients with essential hypertension have impaired functional sympatholysis in the forearm, and reduced exercise hyperaemia in the leg, but this can be normalized by aerobic exercise training. The effect of physical activity on the local mechanisms that modulate sympathetic vasoconstriction is clear, but it remains uncertain which locally released substance(s) block the effect of NA and how this is accomplished. NO and ATP have been proposed as important inhibitors of NA mediated vasoconstriction and presently an inhibitory effect of ATP on NA signalling via P2 receptors appears most likely.
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