ArticleProceedings of the National Academy of Sciences of the United States of America2012
Diet-induced metabolic change induces estrogen-independent allometric mammary growth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Difference in breast size between the first and third trimesters of pregnancy and changes in a woman's body size, subcutaneous fat tissue, and biochemical parameters.Scientific reports · 2026Article
- Development of the mammary glands and its regulation: how not all species are equal.Animal frontiers : the review magazine of animal agriculture · 2023Article
- In Utero Exposure to trans-10, cis-12 Conjugated Linoleic Acid Modifies Postnatal Development of the Mammary Gland and its Hormone Responsiveness.Journal of mammary gland biology and neoplasia · 2021Article
- Folate Deficiency Inhibits Development of the Mammary Gland and its Associated Lymphatics in FVB Mice.The Journal of nutrition · 2020Article
- Weighing the Risk: effects of Obesity on the Mammary Gland and Breast Cancer Risk.Journal of mammary gland biology and neoplasia · 2020Review
- TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Dietary regulation of allometric ductal growth in the mammary glands.Journal of animal science · 2017Review
- The Transcriptome of Estrogen-Independent Mammary Growth in Female Mice Reveals That Not All Mammary Glands Are Created Equally.Endocrinology · 2017Article
- Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific.Lipids · 2017Article
- BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.Cellular and molecular life sciences : CMLS · 2017Review
- Article
- A Convenient Method for Evaluating Epithelial Cell Proliferation in the Whole Mammary Glands of Female Mice.Endocrinology · 2016Article
- Mammary gland development--It's not just about estrogen.Journal of dairy science · 2016Review
- Review
- Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice.International journal of cancer · 2014Article
- Vegetable protein and vegetable fat intakes in pre-adolescent and adolescent girls, and risk for benign breast disease in young women.Breast cancer research and treatment · 2013Article
- Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPARγ Signaling and Inflammation in Murine Mammary Tissue.Journal of lipids · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lifetime breast cancer risk reflects an unresolved combination of early life factors including diet, body mass index, metabolic syndrome, obesity, and age at first menses. In parallel, the onset of allometric growth by the mammary glands around puberty is widely held to be estrogen (E)-dependent. Here we report that several physiological changes associated with metabolic syndrome in response to a diet supplemented with the trans-10, cis-12 isomer of conjugated linoleic acid lead to ovary-independent allometric growth of the mammary ducts. The E-independence of this diet-induced growth was highlighted by the fact that it occurred both in male mice and with pharmacological inhibition of either E receptor function or E biosynthesis. Reversal of the metabolic phenotype with the peroxisome proliferator-activated receptor-γ agonist rosiglitazone abrogated diet-induced mammary growth. A role for hyperinsulinemia and increased insulin-like growth factor-I receptor (IGF-IR) expression during mammary growth induced by the trans-10, cis-12 isomer of conjugated linoleic acid was confirmed by its reversal upon pharmacological inhibition of IGF-IR function. Diet-stimulated ductal growth also increased mammary tumorigenesis in ovariectomized polyomavirus middle T-antigen mice. Our data demonstrate that diet-induced metabolic dysregulation, independently of ovarian function, stimulates allometric growth within the mammary glands via an IGF-IR-dependent mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.