ArticleProceedings of the National Academy of Sciences of the United States of America2012
Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed.
- Deciphering the Function and Structure of PA1216 as an S-Adenosyl-l-Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism.Protein science : a publication of the Protein Society · 2026Article
- Single-cell phenotypic heterogeneity shapes quorum signaling dynamics in Pseudomonas aeruginosa.Nature communications · 2026Article
- The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivo.Drug metabolism and disposition: the biological fate of chemicals · 2025Article
- Collaboration between a temperate phage andmBio · 2025Article
- Modulation of themBio · 2025Article
- Quorum sensing regulation of Psl polysaccharide production byJournal of bacteriology · 2024Article
- The relationship betweenJournal of bacteriology · 2024Article
- qsmR encoding an IclR-family transcriptional factor is a core pathogenic determinant of Burkholderia glumae beyond the acyl-homoserine lactone-mediated quorum-sensing system.PLoS pathogens · 2024Article
- Uncovering a hidden functional role of the XRE-cupin protein PsdR as a novel quorum-sensing regulator in Pseudomonas aeruginosa.PLoS pathogens · 2024Article
- Relationship of the transcription factor MexT to quorum sensing and virulence inJournal of bacteriology · 2023Article
- A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing.Journal of bacteriology · 2023Article
- Signatures of kin selection in a natural population of the bacteriaEvolution letters · 2023Article
- T2SS-peptidase XcpA associated with LasR evolutional phenotypic variations provides a fitness advantage toFrontiers in microbiology · 2023Article
- ModifiedFrontiers in molecular biosciences · 2023Article
- Pseudomonas virulence factor controls expression of virulence genes in Pseudomonas entomophila.PloS one · 2023Article
- The Small RNA AmiL Regulates Quorum Sensing-Mediated Virulence in Pseudomonas aeruginosa PAO1.Microbiology spectrum · 2022Article
- Genetic and Transcriptomic Characteristics of RhlR-Dependent Quorum Sensing in Cystic Fibrosis Isolates of Pseudomonas aeruginosa.mSystems · 2022Article
- Evolution of the Quorum Sensing Regulon in Cooperating Populations of Pseudomonas aeruginosa.mBio · 2022Article
- Sensory Perception in Bacterial Cyclic Diguanylate Signal Transduction.Journal of bacteriology · 2022Review
- Transcriptome Analysis of Pseudomonas aeruginosa Biofilm Infection in anApplied and environmental microbiology · 2022Article
12 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
Quorum sensing allows bacteria to sense and respond to changes in population density. Acyl-homoserine lactones serve as quorum-sensing signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control cooperative activities. Quorum-controlled activities vary from one species to another. Quorum-sensing controls a constellation of genes in the opportunistic pathogen Pseudomonas aeruginosa, which thrives in a number of habitats ranging from soil and water to animal hosts. We hypothesized that there would be significant variation in quorum-sensing regulons among strains of P. aeruginosa isolated from different habitats and that differences in the quorum-sensing regulons might reveal insights about the ecology of P. aeruginosa. As a test of our hypothesis we used RNA-seq to identify quorum-controlled genes in seven P. aeruginosa isolates of diverse origins. Although our approach certainly overlooks some quorum-sensing-regulated genes we found a shared set of genes, i.e., a core quorum-controlled gene set, and we identified distinct, strain-variable sets of quorum-controlled genes, i.e., accessory genes. Some quorum-controlled genes in some strains were not present in the genomes of other strains. We detected a correlation between traits encoded by some genes in the strain-variable subsets of the quorum regulons and the ecology of the isolates. These findings indicate a role for quorum sensing in extension of the range of habitats in which a species can thrive. This study also provides a framework for understanding the molecular mechanisms by which quorum-sensing systems operate, the evolutionary pressures by which they are maintained, and their importance in disparate ecological contexts.
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