ArticlePlant physiology2012
Misexpression of a chloroplast aspartyl protease leads to severe growth defects and alters carbohydrate metabolism in Arabidopsis.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Genome-wide identification and expression analysis of Aspartic proteases in Hordeum vulagare L. reveals candidates involved in salt and drought tolerance.Protoplasma · 2026Article
- PtCP1 Is an Extraplastidial Cysteine Protease Involved in Leaf Protein Degradation ofPlants (Basel, Switzerland) · 2026Article
- Genome-wide identification and expression patterns of the aspartic protease gene family in Epimedium pubescens.BMC genomics · 2025Article
- Histone Maps inInternational journal of molecular sciences · 2023Article
- Chloroplast proteostasis: A story of birth, life, and death.Plant communications · 2023Review
- Phylogenetic and AlphaFold predicted structure analyses provide insights for A1 aspartic protease family classification inFrontiers in plant science · 2023Article
- Genome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population.BMC genomics · 2022Article
- Genome-Wide Analyses of Aspartic Proteases on Potato Genome (Plants (Basel, Switzerland) · 2022Article
- Expression in Escherichia coli, Refolding, and Purification of Plant Aspartic Proteases.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Transcriptomics Reveals Host-Dependent Differences of Polysaccharides Biosynthesis inMolecules (Basel, Switzerland) · 2021Article
- Defense and Offense Strategies: The Role of Aspartic Proteases in Plant-Pathogen Interactions.Biology · 2021Review
- Integrated transcriptome and miRNA analysis uncovers molecular regulators of aerial stem-to-rhizome transition in the medical herb Gynostemma pentaphyllum.BMC genomics · 2019Article
- Genome-wide association study reveals new loci for yield-related traits in Sichuan wheat germplasm under stripe rust stress.BMC genomics · 2019Article
- Genome-wide characterization of aspartic protease (AP) gene family in Populus trichocarpa and identification of the potential PtAPs involved in wood formation.BMC plant biology · 2019Article
- Detection of Highly Differentiated Genomic Regions Between Lotus (Frontiers in plant science · 2018Article
- The Plastid and Mitochondrial Peptidase Network inThe Plant cell · 2017Review
- Ubiquitin-Proteasome Dependent Regulation of the GOLDEN2-LIKE 1 Transcription Factor in Response to Plastid Signals.Plant physiology · 2017Article
- Article
- A trihelix DNA binding protein counterbalances hypoxia-responsive transcriptional activation in Arabidopsis.PLoS biology · 2014Article
- Nighttime sugar starvation orchestrates gibberellin biosynthesis and plant growth in Arabidopsis.The Plant cell · 2013Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crucial role of carbohydrate in plant growth and morphogenesis is widely recognized. In this study, we describe the characterization of nana, a dwarf Arabidopsis (Arabidopsis thaliana) mutant impaired in carbohydrate metabolism. We show that the nana dwarf phenotype was accompanied by altered leaf morphology and a delayed flowering time. Our genetic and molecular data indicate that the mutation in nana is due to a transfer DNA insertion in the promoter region of a gene encoding a chloroplast-located aspartyl protease that alters its pattern of expression. Overexpression of the gene (oxNANA) phenocopies the mutation. Both nana and oxNANA display alterations in carbohydrate content, and the extent of these changes varies depending on growth light intensity. In particular, in low light, soluble sugar levels are lower and do not show the daily fluctuations observed in wild-type plants. Moreover, nana and oxNANA are defective in the expression of some genes implicated in sugar metabolism and photosynthetic light harvesting. Interestingly, some chloroplast-encoded genes as well as genes whose products seem to be involved in retrograde signaling appear to be down-regulated. These findings suggest that the NANA aspartic protease has an important regulatory function in chloroplasts that not only influences photosynthetic carbon metabolism but also plastid and nuclear gene expression.
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