ArticleThe Journal of experimental medicine2012
LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection.
Article in The Journal of experimental medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Review
- At the crux of maternal immune activation: Viruses, microglia, microbes, and IL-17A.Immunological reviews · 2022Review
- Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity.The Journal of experimental medicine · 2021Article
- Granulocytic myeloid-derived suppressor cells inhibit T follicular helper cells during experimental Schistosoma japonicum infection.Parasites & vectors · 2021Article
- Immunity to Influenza Infection in Humans.Cold Spring Harbor perspectives in medicine · 2021Review
- Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.Current opinion in immunology · 2018Review
- Protective neutralizing influenza antibody response in the absence of T follicular helper cells.Nature immunology · 2016Article
- Double-negative T resident memory cells of the lung react to influenza virus infection via CD11c(hi) dendritic cells.Mucosal immunology · 2016Article
- Roads to the development of improved pertussis vaccines paved by immunology.Pathogens and disease · 2015Review
- The regulation of T follicular helper responses during infection.Current opinion in immunology · 2015Review
- Follicular helper T cells promote liver pathology in mice during Schistosoma japonicum infection.PLoS pathogens · 2014Article
- Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.Nature · 2014Article
- Priming of T follicular helper cells by dendritic cells.Immunology and cell biology · 2014Review
- IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection.PloS one · 2014Article
- Viral infection of the lung: host response and sequelae.The Journal of allergy and clinical immunology · 2013Review
- Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus.Immunological reviews · 2013Review
- Role of T cell immunity in recovery from influenza virus infection.Current opinion in virology · 2013Review
- Splenic priming of virus-specific CD8 T cells following influenza virus infection.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The humoral immune response to most respiratory virus infections plays a prominent role in virus clearance and is essential for resistance to reinfection. T follicular helper (Tfh) cells are believed to support the development both of a potent primary antibody response and of the germinal center response critical for memory B cell development. Using a model of primary murine influenza A virus (IAV) infection, we demonstrate that a novel late activator antigen-presenting cell (LAPC) promotes the Tfh response in the draining lymph nodes (dLNs) of the IAV-infected lungs. LAPCs migrate from the infected lungs to the dLN "late," i.e., 6 d after infection, which is concomitant with Tfh differentiation. LAPC migration is CXCR3-dependent, and LAPC triggering of Tfh cell development requires ICOS-ICOSL-dependent signaling. LAPCs appear to play a pivotal role in driving Tfh differentiation of Ag-primed CD4(+) T cells and antiviral antibody responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.