Evidence map›Paper›PMID 22987791›Full record

ArticleChemMedChem2012

Synthesis and structure-activity relationships of lansine analogues as antileishmanial agents.

Marco Pieroni, Sisay Girmay, Dianqing Sun, Rajnish Sahu, Babu L Tekwani, Ghee T Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marco PieroniCollege of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720-4029 (USA); Interdepartmental Center Biopharmanet_TEC, Universita' degli Studi di Parma, Via G. P. Usberti 27, Parma (Italy).
Sisay Girmay
Dianqing Sun
Rajnish Sahu
Babu L Tekwani
Ghee T Tan

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
USING EEG COMPLEXITY AND HIGH PERFORMANCE COMPUTING TO PROFILE SLEEPP20RR016467 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI HOLMES, ERIC · 2001 to 2011
$24.5M
NCRR NIH HHS 5P20RR016467-11NCRR NIH HHS P20 RR016467NIGMS NIH HHS 8 P20 GM103466-11NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

Clear and rational thinking: A series of rationally designed, lansine-derived carbazoles was synthesized and evaluated for activity against promastigotes and amastigotes of Leishmania donovani, the causative agent of leishmaniasis. Some structural modifications gave rise to compounds with enhanced activity and selectivity over lansine, allowing structure-activity relationships to be elucidated and providing a foundation for the further development of this pharmacophore.

Indexed as

AnimalsCell LineChlorocebus aethiopsDrug DesignHumansLeishmania donovaniLeishmaniasisMiceStructure-Activity RelationshipTrypanocidal AgentsVero CellsTrypanocidal Agentsantiparasitic agentscarbazolesdrug designLeishmania donovanileishmaniasis

Identifiers

PMID22987791
PMCPMC3565020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.