Evidence map›Paper›PMID 22987727›Full record

ReviewReviews in medical virology2012

Potential strategies and biosafety protocols used for dual-use research on highly pathogenic influenza viruses.

Lanying Du, Ye Li, Jimin Gao, Yusen Zhou, Shibo Jiang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews in medical virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Lanying DuLindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.
Ye Li
Jimin Gao
Yusen Zhou
Shibo Jiang
Wenzhou Medical University · CNInstitute of Microbiology · CNNew York Blood Center · USShanghai Medical College of Fudan University · CN

Funding

Rational design of M2e-FP conserved epitope-based universal influenza A vaccinesR03AI088449 · NIAID · NEW YORK BLOOD CENTER · PI DU, LANYING · 2011 to 2012
$162k
NIAID NIH HHS R03 AI088449NIAID NIH HHS R03AI088449
6 · The paper itself

Abstract

Influenza A viruses (IAVs), particularly the highly pathogenic avian influenza H5N1, have posed a substantial threat to public health worldwide. Although the laboratory generation of the mutant influenza virus H5N1 with airborne transmissibility among mammals, which has been considered as a dual-use research, may benefit the development of effective vaccines and therapeutics against the emerging infectious agents, it may also pose threats to national biosecurity, laboratory biosafety, and/or public health. This review introduces the classification and characterization of IAVs, pinpoints historic pandemics and epidemics caused by IAVs, emphasizes the significance and necessity of biosafety, summarizes currently established biosafety-related protocols for IAV research, and provides potential strategies to improve biosafety protocols for dual-use research on the highly pathogenic avian influenza viruses and other emerging infectious agents.

Indexed as

AnimalsHumansInfluenza A virusInfluenza A Virus, H5N1 SubtypeInfluenza, HumanOccupational HealthOrthomyxoviridae InfectionsPublic HealthResearch

Identifiers

PMID22987727
PMCPMC3580078
OpenAlexW1804227875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.