ArticleHippocampus2012
Layer V perirhinal cortical ensemble activity during object exploration: a comparison between young and aged rats.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- An operant-based touchscreen morph discrimination task does not detect age-related mnemonic similarity deficits in rats.Oxford open neuroscience · 2026Article
- Tell me why: the missing w in episodic memory's what, where, and when.Cognitive, affective & behavioral neuroscience · 2025Review
- 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022Review
- Unilateral Perforant Path Transection Does Not Alter Lateral Entorhinal Cortical or Hippocampal CA3Frontiers in systems neuroscience · 2022Article
- Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.Hippocampus · 2021Review
- The Perirhinal Cortex Engages in Area and Layer-Specific Encoding of Item Dimensions.Frontiers in behavioral neuroscience · 2021Article
- Age-Related Alterations in Prelimbic Cortical NeuronFrontiers in aging neuroscience · 2020Article
- What are the later life contributions to reserve, resilience, and compensation?Neurobiology of aging · 2019Article
- Aged rats with intact memory show distinctive recruitment in cortical regions relative to young adults in a cue mismatch task.Behavioral neuroscience · 2019Article
- Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.Neurobiology of aging · 2018Article
- Behavioral tagging and capture: long-term memory decline in middle-aged rats.Neurobiology of aging · 2018Article
- Impaired discrimination with intact crossmodal association in aged rats: A dissociation of perirhinal cortical-dependent behaviors.Behavioral neuroscience · 2018Article
- Experience-Dependent Effects of Muscimol-Induced Hippocampal Excitation on Mnemonic Discrimination.Frontiers in systems neuroscience · 2018Article
- Intact perceptual ability, but impaired familiarity judgment, after neonatal perirhinal lesions in rhesus macaques.Developmental cognitive neuroscience · 2017Article
- Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.Neurobiology of aging · 2017Article
- Medial prefrontal-perirhinal cortical communication is necessary for flexible response selection.Neurobiology of learning and memory · 2017Article
- Age-related Changes in Lateral Entorhinal and CA3 Neuron Allocation Predict Poor Performance on Object Discrimination.Frontiers in systems neuroscience · 2017Article
- Discrimination performance in aging is vulnerable to interference and dissociable from spatial memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Object and spatial memory after neonatal perirhinal lesions in monkeys.Behavioural brain research · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Object recognition memory requires the perirhinal cortex (PRC) and this cognitive function declines during normal aging. Recent electrophysiological recordings from young rats have shown that neurons in Layer V of the PRC are activated by three-dimensional objects. Thus, it is possible that age-related object recognition deficits result from alterations in PRC neuron activity in older animals. To examine this, the present study used cellular compartment analysis of temporal activity by fluorescence in situ hybridization (catFISH) with confocal microscopy to monitor cellular distributions of activity-induced Arc RNA in layer V of the PRC. Activity was monitored during two distinct epochs of object exploration. In one group of rats (6 young/6 aged) animals were placed in a familiar testing arena and allowed to explore five different three-dimensional objects for two 5-min sessions separated by a 20-min rest (AA). The second group of animals (6 young/6 aged) also explored the same objects for two 5-min sessions, but the environment was changed between the first and the second epoch (AB). Behavioral data showed that both age groups spent less time exploring objects during the second epoch, even when the environment changed, indicating successful recognition. Although the proportion of active neurons between epochs did not change in the AA group, in the AB group more neurons were active during epoch 2 of object exploration. This recruitment of neurons into the active neural ensemble could serve to signal that familiar stimuli are being encountered in a new context. When numbers of Arc positive neurons were compared between age groups, the old rats had significantly lower proportions of Arc-positive PRC neurons in both the AA and AB behavioral conditions. These data support the hypothesis that age-associated functional alterations in the PRC contribute to declines in stimulus recognition over the lifespan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.