ArticleHippocampus2012
Recognition memory and synaptic plasticity in the perirhinal and prefrontal cortices.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Detecting Fear-Memory-Related Genes from Neuronal scRNA-seq Data by Diverse Distributions and Bhattacharyya Distance.Biomolecules · 2022Article
- Enhanced Written vs. Verbal Recall Accuracy Associated With Greater Prefrontal Activation: A Near-Infrared Spectroscopy Study.Frontiers in behavioral neuroscience · 2021Article
- Multi-level analyses of associative recognition memory: the whole is greater than the sum of its parts.Current opinion in behavioral sciences · 2020Review
- Delay-Dependent Impairments in Memory and Motor Functions After Acute Methadone Overdose in Rats.Frontiers in pharmacology · 2018Article
- Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Dopamine and Consolidation of Episodic Memory: Timing is Everything.Journal of cognitive neuroscience · 2015Article
- In search of a recognition memory engram.Neuroscience and biobehavioral reviews · 2015Review
- Molecular mechanisms of memory in imprinting.Neuroscience and biobehavioral reviews · 2015Review
- Object-in-place associative recognition memory depends on glutamate receptor neurotransmission within two defined hippocampal-cortical circuits: a critical role for AMPA and NMDA receptors in the hippocampus, perirhinal, and prefrontal cortices.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Investigations into the involvement of NMDA mechanisms in recognition memory.Neuropharmacology · 2013Review
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Authors and funding
3 authors.
Funding
Abstract
Work is reviewed that relates recognition memory to studies of synaptic plasticity mechanisms in perirhinal and prefrontal cortices. The aim is to consider evidence that perirhinal cortex and medial prefrontal cortex store rather than merely transmit information necessary for recognition memory and, if so, to consider what mechanisms are potentially available within these cortices for producing such storage through synaptic change. Interventions with known actions on plasticity mechanisms are reviewed in relation to their effects on recognition memory processes. These interventions importantly include those involving antagonism of glutamatergic and cholinergic receptors but also inhibition of plasticity consolidation and expression mechanisms. It is concluded that there is strong evidence that perirhinal cortex is involved in information storage necessary for object recognition memory and, moreover, that such storage involves synaptic weakening mechanisms including the removal of AMPA glutamate receptors from synapses. There is good evidence that medial prefrontal cortex is necessary for associative and temporal order recognition memory and that this cortex expresses plasticity mechanisms that potentially allow the storage of information. However, the case for medial prefrontal cortex acting as a store requires further support.
Indexed as
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22987679What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.