Trial reportHippocampus2012
Age-related impairment in a complex object discrimination task that engages perirhinal cortex.
Trial report in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- An operant-based touchscreen morph discrimination task does not detect age-related mnemonic similarity deficits in rats.Oxford open neuroscience · 2026Article
- A novel composite biomarker score for the identification of cognitive impairment in patients with heart failure: a pilot study.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2025Article
- Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions.Neurobiology of aging · 2025Article
- Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice.Frontiers in aging neuroscience · 2025Article
- The need for details for object discrimination and mnemonic discrimination.Frontiers in cognition · 2025Article
- Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan.Journal of experimental psychology. General · 2024Article
- Multisensory perception constrains the formation of object categories: a review of evidence from sensory-driven and predictive processes on categorical decisions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Article
- Executive function and high ambiguity perceptual discrimination contribute to individual differences in mnemonic discrimination in older adults.Cognition · 2021Article
- An fMRI study of age-associated changes in basic visual discrimination.Brain imaging and behavior · 2021Article
- Age-related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields.Hippocampus · 2021Article
- Dedifferentiation of Functional Brain Activation Associated With Greater Visual Discrimination Accuracy in Middle-Aged and Older Adults.Frontiers in aging neuroscience · 2021Article
- Healthy Middle-Aged Adults Have Preserved Mnemonic Discrimination and Integration, While Showing No Detectable Memory Benefits.Frontiers in psychology · 2021Article
- Spatial Pattern Separation Testing Differentiates Alzheimer's Disease Biomarker-Positive and Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective.Frontiers in systems neuroscience · 2021Article
- Age-Related Regional Network Covariance of Magnetic Resonance Imaging Gray Matter in the Rat.Frontiers in aging neuroscience · 2020Article
- A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats.Frontiers in aging neuroscience · 2020Article
- Age-Related Alterations in Prelimbic Cortical NeuronFrontiers in aging neuroscience · 2020Article
- Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Previous lesion studies have shown compromised complex object discrimination in rats, monkeys, and human patients with damage to the perirhinal cortical region (PRC) of the medial temporal lobe. These findings support the notion that the PRC is involved in object discrimination when pairs of objects have a high degree of overlapping features but not when object discrimination can be resolved on the basis of a single feature (e.g., size or color). Recent studies have demonstrated age-related functional changes to the PRC in animals (rats and monkeys) resulting in impaired complex object discrimination and object recognition. To date, no studies have compared younger and older humans using paradigms previously shown to engage the PRC. To investigate the influence of age on complex object discrimination in humans, the present study used an object matching paradigm for blob-like objects that have previously been shown to recruit the PRC. Difficulty was manipulated by varying the number of overlapping features between objects. Functional MRI data was acquired to determine the involvement of the PRC in the two groups during complex object discrimination. Results indicated that while young and older adults performed similarly on the easy version of the task, most older adults were impaired relative to young participants when the number of overlapping features increased. fMRI results suggest that older adults do not engage bilateral anterior PRC to the same extent as young adults. Specifically, complex object matching performance in older adults was predicted by the degree to which they engage left anterior PRC. These results provide evidence for human age-related changes in PRC function that impact complex object discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.