ArticleThe American journal of tropical medicine and hygiene2012
Cytokine factors present in dengue patient sera induces alterations of junctional proteins in human endothelial cells.
Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Induction of PD-1 and CD44 in CD4Journal of virology · 2025Article
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- Cross Talk between MicroRNAs and Dengue Virus.The American journal of tropical medicine and hygiene · 2024Review
- Prevention, diagnosis, and treatment protocol of dengue during pregnancy and the postpartum period.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Review
- Potential Protective Effect of Dengue NS1 Human Monoclonal Antibodies against Dengue and Zika Virus Infections.Biomedicines · 2023Article
- The Role of Growth Factors in the Pathogenesis of Dengue: A Scoping Review.Pathogens (Basel, Switzerland) · 2022Article
- Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner.Pathogens (Basel, Switzerland) · 2022Article
- Comparative cytokine profiling identifies common and unique serum cytokine responses in acute chikungunya and dengue virus infection.BMC infectious diseases · 2021Article
- Blood Levels of Galectin-9, an Immuno-Regulating Molecule, Reflect the Severity for the Acute and Chronic Infectious Diseases.Biomolecules · 2021Review
- Dengue virus-elicited tryptase induces endothelial permeability and shock.The Journal of clinical investigation · 2019Article
- Review
- Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques.PloS one · 2018Article
- Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections.Frontiers in immunology · 2018Review
- Pathogenesis of vascular leak in dengue virus infection.Immunology · 2017Review
- Mathematical modelling and a systems science approach to describe the role of cytokines in the evolution of severe dengue.BMC systems biology · 2017Article
- Secretory phospholipase A2 in the pathogenesis of acute dengue infection.Immunity, inflammation and disease · 2017Article
- Article
- IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever.Mediators of inflammation · 2017Article
- Platelet activating factor contributes to vascular leak in acute dengue infection.PLoS neglected tropical diseases · 2015Article
- STAT2 signaling and dengue virus infection.JAK-STAT · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma leakage in severe dengue has been postulated to be associated with skewed cytokine immune responses. In this study, the association of cytokines with vascular permeability in dengue patients was investigated. Human serum samples collected from 48 persons (13 with dengue fever, 29 with dengue hemorrhagic fever, and 6 healthy) were subjected to cytokines analysis by using Luminex Multiplex Technology. Selected serum samples from patients with dengue hemorrhagic fever sera and recombinant human cytokines were then tested for roles on inducing vascular permeability by treatment of human umbilical vein endothelial cells. Confocal immunofluorescence staining indicated morphologic alteration of human umbilical vein endothelial cells treated with serum samples from patients with dengue hemorrhagic fever compared with serum samples from healthy persons. The findings suggest that cytokines produced during dengue hemorrhagic infections could induce alterations in the vascular endothelium, which may play a fundamental role in the pathophysiology of dengue.
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