ArticleGenes & development2012
Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- From Adult Morphology to Developmental Hypothesis: Variation of the Adult Lateral Wrist Extensors-A Developmental Viewpoint.Journal of functional morphology and kinesiology · 2026Article
- Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence.Cell reports · 2025Article
- Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.PLoS genetics · 2024Article
- Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function.Communications biology · 2023Article
- Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration.Nature communications · 2023Article
- Targeting the Hedgehog Pathway in Rhabdomyosarcoma.Cancers · 2023Review
- Distinct patterning responses of wing and leg neuromuscular systems to different preaxial polydactylies.Frontiers in cell and developmental biology · 2023Article
- Digits in a dish: AnFrontiers in cell and developmental biology · 2023Article
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations.Cell reports · 2022Article
- A genetic screen for regulators of muscle morphogenesis in Drosophila.G3 (Bethesda, Md.) · 2021Article
- Gli1 Defines a Subset of Fibro-adipogenic Progenitors that Promote Skeletal Muscle Regeneration With Less Fat Accumulation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Time-resolved proteomics profiling of the ciliary Hedgehog response.The Journal of cell biology · 2021Article
- Developmental and regenerative paradigms of cilia regulated hedgehog signaling.Seminars in cell & developmental biology · 2021Review
- Master control: transcriptional regulation of mammalian Myod.Journal of muscle research and cell motility · 2019Review
- Muscle precursor cell movements in zebrafish are dynamic and require Six family genes.Development (Cambridge, England) · 2019Article
- FACS-Seq analysis of Pax3-derived cells identifies non-myogenic lineages in the embryonic forelimb.Scientific reports · 2018Article
- Article
- Sonic Hedgehog Signaling in Limb Development.Frontiers in cell and developmental biology · 2017Review
- Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Muscle progenitor cells migrate from the lateral somites into the developing vertebrate limb, where they undergo patterning and differentiation in response to local signals. Sonic hedgehog (Shh) is a secreted molecule made in the posterior limb bud that affects patterning and development of multiple tissues, including skeletal muscles. However, the cell-autonomous and non-cell-autonomous functions of Shh during limb muscle formation have remained unclear. We found that Shh affects the pattern of limb musculature non-cell-autonomously, acting through adjacent nonmuscle mesenchyme. However, Shh plays a cell-autonomous role in maintaining cell survival in the dermomyotome and initiating early activation of the myogenic program in the ventral limb. At later stages, Shh promotes slow muscle differentiation cell-autonomously. In addition, Shh signaling is required cell-autonomously to regulate directional muscle cell migration in the distal limb. We identify neuroepithelial cell transforming gene 1 (Net1) as a downstream target and effector of Shh signaling in that context.
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