ArticleGenes & development2012
Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Organization principles of dynamic three-dimensional genome architecture associated with centromere clustering states.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Combinatorial Analyses of Pre-mRNA Splicing-Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
- Roles of Specialized Chromatin and DNA Structures at Subtelomeres inBiomolecules · 2023Review
- The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin.Life (Basel, Switzerland) · 2021Article
- Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Journal of molecular biology · 2020Review
- Heterochromatin replication goes hand in hand with telomere protection.Nature structural & molecular biology · 2020Review
- Unprogrammed epigenetic variation mediated by stochastic formation of ectopic heterochromatin.Current genetics · 2020Review
- Control of DNA replication timing in the 3D genome.Nature reviews. Molecular cell biology · 2019Review
- Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast.PLoS genetics · 2019Article
- Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins.Scientific reports · 2019Article
- Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.PLoS genetics · 2019Article
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- Review
- Review
- Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.The EMBO journal · 2018Article
- Replication timing and nuclear structure.Current opinion in cell biology · 2018Review
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- Oligomer formation and G-quadruplex binding by purified murine Rif1 protein, a key organizer of higher-order chromatin architecture.The Journal of biological chemistry · 2018Article
- Dependency of Heterochromatin Domains on Replication Factors.G3 (Bethesda, Md.) · 2018Article
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Authors and funding
11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, the replication of chromosome DNA is coordinated by a replication timing program that temporally regulates the firing of individual replication origins. However, the molecular mechanism underlying the program remains elusive. Here, we report that the telomere-binding protein Taz1 plays a crucial role in the control of replication timing in fission yeast. A DNA element located proximal to a late origin in the chromosome arm represses initiation from the origin in early S phase. Systematic deletion and substitution experiments demonstrated that two tandem telomeric repeats are essential for this repression. The telomeric repeats recruit Taz1, a counterpart of human TRF1 and TRF2, to the locus. Genome-wide analysis revealed that Taz1 regulates about half of chromosomal late origins, including those in subtelomeres. The Taz1-mediated mechanism prevents Dbf4-dependent kinase (DDK)-dependent Sld3 loading onto the origins. Our results demonstrate that the replication timing program in fission yeast uses the internal telomeric repeats and binding of Taz1.
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