ArticleCerebellum (London, England)2013
Magnetic resonance spectroscopy of the normal cerebellum: what degree of variability can be expected?
Article in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- MR spectroscopy of the cerebellum in gluten ataxia and gluten encephalopathy.Journal of neurology · 2026Article
- Gluten Ataxia in Children and Adolescents.Cerebellum (London, England) · 2026Article
- The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Regional Striatal Cholinergic Involvement in Human Behavioral Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- IsCerebellum & ataxias · 2019Article
- Correlation between cerebellar metabolism and post-stroke depression in patients with ischemic stroke.Oncotarget · 2017Article
- Cerebellum and neurodegenerative diseases: Beyond conventional magnetic resonance imaging.World journal of radiology · 2017Review
- Alcohol-related cerebellar degeneration: not all down to toxicity?Cerebellum & ataxias · 2016Article
- Reproducibility and effect of tissue composition on cerebellar γ-aminobutyric acid (GABA) MRS in an elderly population.NMR in biomedicine · 2015Article
- Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single-voxel MRS at 3T.Magnetic resonance in medicine · 2015Article
- Miller-Fisher Syndrome: Is the ataxia central or peripheral?Cerebellum & ataxias · 2015Article
- Metabolic evidence for cerebral neurodegeneration in spinocerebellar ataxia type 1.Cerebellum (London, England) · 2014Article
- Alcohol induces sensitization to gluten in genetically susceptible individuals: a case control study.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objectives of this paper are (a) to establish the reliability of relative metabolite concentrations determined with (1)H-MR spectroscopy of the cerebellum using a method appropriate to the constraints of clinical radiology and (b) to record normal values for metabolites within the cerebellum and to look for differences in metabolite concentrations between the cerebellar hemispheric white matter and the superior vermis. 3-T (1)H-MR spectra were obtained from voxels positioned in the right cerebellar hemispheric white matter and the superior vermis in 55 healthy adults (mean age 41 years, range 20 to 77) using a single voxel PRESS sequence (TR/TE = 2,000/144 ms). One volunteer (male, age 34 years) was examined in six separate sessions over a period of 3 weeks. Reliability of intra- and inter-subject metabolite fitted area ratios was determined by evaluating coefficients of variance (%). Inter- and intra-subject coefficients of variance (%) in metabolite ratios were consistently lower in the vermis (4 to 11.6) compared to those of the hemisphere (7.2 to 14.3). Cho/Cr was significantly higher in the vermis (0.83 ± 0.10) compared to the hemisphere (0.76 ± 0.11) and NAA/Cho was significantly lower in the vermis (1.19 ± 0.12) compared to the hemisphere (1.35 ± 0.16). Low inter- and intra-subject variability can be achieved when using a (1)H-MR spectroscopy technique that is appropriate to the time constraints of clinical radiology. The regional variations of Cho/Cr and NAA/Cho within the hemisphere and vermis should be considered when performing studies of diseases, which may preferentially target a particular cerebellar location.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.