Trial reportInternational journal of hematology2012
Role of CD61+ cells in thrombocytopenia of dengue patients.
Trial report in International journal of hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Increased Plasma Concentrations of Extracellular Vesicles Are Associated with Pro-Inflammatory and Pro-Thrombotic Characteristics of Left and Right Ventricle Mechanical Support Devices.Journal of cardiovascular development and disease · 2023Article
- Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis.Frontiers in immunology · 2022Review
- Thrombocytopenia in Virus Infections.Journal of clinical medicine · 2021Review
- Investigation of the efficacy and safety of eltrombopag to correct thrombocytopenia in moderate to severe dengue patients - a phase II randomized controlled clinical trial.EClinicalMedicine · 2020Article
- From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation.Biology · 2020Review
- Dengue viruses infect human megakaryocytes, with probable clinical consequences.PLoS neglected tropical diseases · 2019Article
- Dengue type 1 viruses circulating in humans are highly infectious and poorly neutralized by human antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The role of lipids in the inception, maintenance and complications of dengue virus infection.Scientific reports · 2018Article
- Selective Tropism of Dengue Virus for Human Glycoprotein Ib.Scientific reports · 2018Article
- Article
- Involvement of fatty acid synthase in dengue virus infection.Virology journal · 2017Article
- Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever.PLoS neglected tropical diseases · 2016Article
- Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance.Scientific reports · 2015Article
- Microparticles provide a novel biomarker to predict severe clinical outcomes of dengue virus infection.Journal of virology · 2015Article
- Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators.Mediators of inflammation · 2015Review
- The role of platelets in the pathogenesis of viral hemorrhagic fevers.PLoS neglected tropical diseases · 2014Review
- Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome.Journal of biomedical science · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Although hematological disorders with salient features of thrombocytopenia have been well documented in dengue patients, the role of CD61-expressing platelets and the megakaryocytic cell lineage in the pathogenesis of dengue virus (DENV) infection remains largely unexplored. A prospective observational study was performed using blood samples and PBMCs from dengue-confirmed patients, as well as from rhesus monkeys (RM) experimentally infected with DENV. Immunohistochemical staining and FACS techniques were applied to evaluate the frequencies of CD61(+) cells that contained DENV antigen. Highly enriched population of CD61(+) cells was also isolated from acute DENV-infected RM and assayed for DENV RNA by quantitative RT-PCR. Results revealed that DENV antigen was found in small vesicles of varying size, and more frequently in anucleated cells associated with platelets in dengue patients. The DENV antigen-containing cells were CD61(+) and appeared to share characteristics of megakaryocytes. Kinetic profiles of CD61(+) cells from DENV-infected RM revealed a transient increase in CD61(+)CD62P(+) cells early after DENV infection. DENV RNA in a highly enriched population of CD61(+) cells from the infected RM was observed during acute stage. Our results indicate that virus containing CD61(+) cells may be directly linked to the platelet dysfunction and low platelet count characteristics of dengue patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.