ArticleCell cycle (Georgetown, Tex.)2012
Hypoxia and gerosuppression: the mTOR saga continues.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning.Frontiers in genetics · 2020Review
- Cell Senescence in Lupus.Current rheumatology reports · 2019Review
- Review
- Induction of dormancy in hypoxic human papillomavirus-positive cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- HIF-1α and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress.Cell cycle (Georgetown, Tex.) · 2016Article
- Nutrient-Deprived Retinal Progenitors Proliferate in Response to Hypoxia: Interaction of the HIF-1 and mTOR Pathway.Journal of developmental biology · 2016Article
- Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases.Aging and disease · 2016Review
- Article
- Gerosuppression in confluent cells.Aging · 2014Article
- A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling.Oncotarget · 2014Article
- Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Stem cells, redox signaling, and stem cell aging.Antioxidants & redox signaling · 2014Review
- Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.Cell cycle (Georgetown, Tex.) · 2014Article
- S6K in geroconversion.Cell cycle (Georgetown, Tex.) · 2013Article
- Molecular dynamics of the full-length p53 monomer.Cell cycle (Georgetown, Tex.) · 2013Article
- MEK drives cyclin D1 hyperelevation during geroconversion.Cell death and differentiation · 2013Article
- Article
- Article
- Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents.Cell cycle (Georgetown, Tex.) · 2013Article
- Running m(o)TOR with the brakes on leads to catastrophe at mitosis.Cell cycle (Georgetown, Tex.) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth-promoting and nutrient/mitogen-sensing pathways such as mTOR convert p21- and p16-induced arrest into senescence (geroconversion). We have recently demonstrated that hypoxia, especially near-anoxia, suppresses geroconversion. This gerosuppressive effect of hypoxia correlated with inhibition of the mTOR/S6K pathway but not with modulation of the LKB1/AMPK/eEF2 pathway. Here we further show that mTOR inhibition is required for gerosuppression by hypoxia, at least in some cellular models, because depletion of TSC2 abolished mTOR inhibition and gerosupression by hypoxia. Also, in two cancer cell lines resistant to inhibition of mTOR by both p53 and hypoxia, hypoxia did not suppress geroconversion. Therefore, the effects of hypoxia on the oxygen-sensing mTOR pathway and geroconversion are cell type-specific. We also briefly discuss replicative senescence, organismal aging and free radical theory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.