ArticleIEEE transactions on nanobioscience2012
ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections.
Article in IEEE transactions on nanobioscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- The Future Exploring of Gut Microbiome-Immunity Interactions: From In Vivo/Vitro Models to In Silico Innovations.Microorganisms · 2024Review
- TowardsFrontiers in bioengineering and biotechnology · 2021Review
- A software package for immunologists to learn simulation modeling.BMC immunology · 2020Article
- Fast and near-optimal monitoring for healthcare acquired infection outbreaks.PLoS computational biology · 2019Article
- Host-microbe interaction in the gastrointestinal tract.Environmental microbiology · 2018Review
- Review of the systems biology of the immune system using agent-based models.IET systems biology · 2018Review
- Cooperation of Gastric Mononuclear Phagocytes withJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Model of Host-Pathogen Interaction Dynamics Links In Vivo Optical Imaging and Immune Responses.Infection and immunity · 2017Article
- Modeling-Enabled Systems Nutritional Immunology.Frontiers in nutrition · 2016Review
- Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection.PloS one · 2016Article
- Computational Studies of the Intestinal Host-Microbiota Interactome.Computation (Basel, Switzerland) · 2015Article
- Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection.PloS one · 2015Article
- Introduction of a Framework for Dynamic Knowledge Representation of the Control Structure of Transplant Immunology: Employing the Power of Abstraction with a Solid Organ Transplant Agent-Based Model.Frontiers in immunology · 2015Article
- Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection.PloS one · 2015Article
- Multiscale modeling of mucosal immune responses.BMC bioinformatics · 2015Article
- Agent-based model of fecal microbial transplant effect on bile acid metabolism on suppressing Clostridium difficile infection: an example of agent-based modeling of intestinal bacterial infection.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- Investigation of inflammation and tissue patterning in the gut using a Spatially Explicit General-purpose Model of Enteric Tissue (SEGMEnT).PLoS computational biology · 2014Article
- Computational modeling of heterogeneity and function of CD4+ T cells.Frontiers in cell and developmental biology · 2014Review
- Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection.PloS one · 2013Article
- ENteric Immunity SImulator: a tool for in silico study of gastroenteric infections.IEEE transactions on nanobioscience · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Clinical symptoms of microbial infection of the gastrointestinal (GI) tract are often exacerbated by inflammation induced pathology. Identifying novel avenues for treating and preventing such pathologies is necessary and complicated by the complexity of interacting immune pathways in the gut, where effector and inflammatory immune cells are regulated by anti-inflammatory or regulatory cells. Here we present new advances in the development of the ENteric Immunity SImulator (ENISI), a simulator of GI immune mechanisms in response to resident commensal bacteria as well as invading pathogens and the effect on the development of intestinal lesions. ENISI is a tool for identifying potential treatment strategies that reduce inflammation-induced damage and, at the same time, ensure pathogen removal by allowing one to test plausibility of in vitro observed behavior as explanations for observations in vivo, propose behaviors not yet tested in vitro that could explain these tissue-level observations, and conduct low-cost, preliminary experiments of proposed interventions/treatments. An example of such application is shown in which we simulate dysentery resulting from Brachyispira hyodysenteriae infection and identify aspects of the host immune pathways that lead to continued inflammation-induced tissue damage even after pathogen elimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.