ArticleThe pharmacogenomics journal2013
Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.
Article in The pharmacogenomics journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Pooled it
- Exploring the Potential Association Between Inhaled Corticosteroid and Face Aging Risk: A Mendelian Randomization Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Glucocorticoid receptor-mediatediScience · 2023Article
- Identification ofJournal of personalized medicine · 2021Article
- ORMDL3 but not neighboring 17q21 gene LRRC3C is expressed in human lungs and lung cells of asthmatics.Allergy · 2020Article
- Childhood asthma in the new omics era: challenges and perspectives.Current opinion in allergy and clinical immunology · 2020Review
- Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy.Respiratory research · 2020Article
- Pharmacogenomic Response of Inhaled Corticosteroids for the Treatment of Asthma: Considerations for Therapy.Pharmacogenomics and personalized medicine · 2020Review
- Pharmacogenetics of Pediatric Asthma: Current Perspectives.Pharmacogenomics and personalized medicine · 2020Review
- Article
- The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.American journal of respiratory and critical care medicine · 2019Article
- Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review.Clinical and translational allergy · 2019Review
- Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.Frontiers in pharmacology · 2019Review
- 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.Allergy · 2018Article
- Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for "Omics" Technology?BioMed research international · 2018Review
- Effects of genetic factors to inhaled corticosteroid response in children with asthma: a literature review.The Journal of international medical research · 2017Review
- Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.Pharmacogenomics · 2017Article
- Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells.PloS one · 2017Article
- Article
- [Research advances in gene polymorphisms in biological pathways of drugs for asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21. We analyzed the effect of functional SNP rs2872507 in ORMDL3 gene region on the response to antiasthmatic treatment with inhaled corticosteroids (ICSs) and ORMDL3 gene expression. Forced expiratory volume in 1 s increased significantly by 13.3% of predicted value after therapy in atopic asthmatics with AA genotype, compared with 7.0% in heterozygotes and 4.9% increase in GG homozygotes (P=0.0176). Median relative expression of ORMDL3 gene in asthmatics with AA, AG and GG genotypes was 0.75, 1.05 and 1.21, respectively (P<0.0001). Treatment with ICSs was significantly associated with the increase of median relative expression of ORMDL3 gene, from 0.88 to 1.21 (P=0.0032) in atopic asthmatics. Our results suggest that rs2872507 is associated with ORMDL3 gene expression and with ICS treatment response in children with atopic asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.