Evidence map›Paper›PMID 22986896›Full record

ArticleThe international journal of cardiovascular imaging2013

Inter-individual variance and cardiac cycle dependency of aortic root dimensions and shape as assessed by ECG-gated multi-slice computed tomography in patients with severe aortic stenosis prior to transcatheter aortic valve implantation: is it crucial for correct sizing?

Lukas Lehmkuhl, Borek Foldyna, Konstantin Von Aspern, Christian Lücke, Matthias Grothoff, Stefan Nitzsche, Jörg Kempfert, Martin Haensig, Ardawan Rastan, Thomas Walther and 2 more

Abstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Preoperative TAVR Planning: How to Do It.Journal of clinical medicine · 2022
    Review
  5. Tumor necrosis factor-α promotes and exacerbates calcification in heart valve myofibroblast populations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  6. Article
  7. Computed tomography guided sizing for transcatheter pulmonary valve replacement.International journal of cardiology. Heart & vasculature · 2020
    Article
  8. Review
  9. Review
  10. Cardiac Computed Tomography - More Than Coronary Arteries? A Clinical Update.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2019
    Review
  11. Article
  12. Article
  13. Anatomy of the aortic root: implications for aortic root reconstruction.General thoracic and cardiovascular surgery · 2017
    Review
  14. Article
  15. Review
  16. Article
  17. Observational
  18. Article
  19. Cardiovascular imaging 2013 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lukas LehmkuhlDepartment of Diagnostic and Interventional Radiology, University of Leipzig-Heart Centre, Strümpellstrasse 39, 04289 Leipzig, Germany. lukas.lehmkuhl@med.uni-leipzig.de
Borek Foldyna
Konstantin Von Aspern
Christian Lücke
Matthias Grothoff
Stefan Nitzsche
Jörg Kempfert
Martin Haensig
Ardawan Rastan
Thomas Walther
Friedrich-Wilhelm Mohr
Matthias Gutberlet

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the inter-individual variance and the variability of the aortic root dimensions during the cardiac cycle by computed tomography (CT) in patients with severe aortic stenosis prior to transcatheter aortic valve implantation (TAVI). Fifty-six patients (m/w = 16/40, 81 ± 6.8 years), scheduled for a transapical aortic valve implantation with available preprocedural ECG-gated CT were retrospectively included. The evaluation included sizing of the aortic annulus and the aortic sinus, measurements of the coronary topography, aortic valve planimetry and scoring of calcification. The new defined aortic annulus sphericity ratio revealed a mostly elliptical shape with increasing diastolic deformation. The calculated effective diameter (ED), determined from the annulus' lumen area, turned out to be the parameter least affected from cardiac cycle changes while systolic and diastolic annulus dimensions and shape (diameter and area) differed significantly (p < 0.001). In about 70 % of the patients with relevant paravalvular leaks the finally implanted prosthesis was too small according to the CT based calculated ED. The ostial height of the coronaries showed a high variability with a critical minimum range <5 mm. The degree of the aortic calcification did not have an influence on the aortic annulus deformation during the cardiac cycle, but on the occurrence of paravalvular leaks. The aortic root anatomy demonstrated a high inter-individual variability and cardiac cycle dependency. These results must be strongly considered during the patient evaluation prior to TAVI to avoid complications. The systolic effective diameter, as measured by ECG-gated CT, represents an appropriate parameter for sizing the aortic annulus.

Indexed as

Cardiac-Gated Imaging TechniquesElectrocardiographyHeart Valve ProsthesisMultidetector Computed TomographyAgedAged, 80 and overAortic ValveAortic Valve StenosisCardiac CatheterizationFemaleHeart Valve Prosthesis ImplantationHumansLinear ModelsMaleMiddle AgedPredictive Value of Tests

Identifiers

PMID22986896
PMCPMC3608865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.