ArticleThe Journal of cell biology2012
Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- A Stable Chemokine Gradient Controls Directional Persistence of Migrating Dendritic Cells.Frontiers in cell and developmental biology · 2022Article
- Sperm chemotaxis in marine species is optimal at physiological flow rates according theory of filament surfing.PLoS computational biology · 2021Article
- Article
- Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm.PLoS computational biology · 2020Article
- A hydrodynamic-stochastic model of chemotactic ciliated microorganisms.The European physical journal. E, Soft matter · 2019Article
- Decision making improves sperm chemotaxis in the presence of noise.PLoS computational biology · 2018Article
- A computational model for how cells choose temporal or spatial sensing during chemotaxis.PLoS computational biology · 2018Article
- A coordinated sequence of distinct flagellar waveforms enables a sharp flagellar turn mediated by squid sperm pH-taxis.Scientific reports · 2017Article
- Article
- Sperm navigation along helical paths in 3D chemoattractant landscapes.Nature communications · 2015Article
- Spatiotemporal analysis of different mechanisms for interpreting morphogen gradients.Biophysical journal · 2015Article
- The CatSper channel controls chemosensation in sea urchin sperm.The EMBO journal · 2015Article
- Chemotactic response with a constant delay-time mechanism in Ciona spermatozoa revealed by a high time resolution analysis of flagellar motility.Biology open · 2015Article
- Rectified directional sensing in long-range cell migration.Nature communications · 2014Article
- High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor.The Journal of cell biology · 2014Article
- Intracellular pH in sperm physiology.Biochemical and biophysical research communications · 2014Review
- Article
- Cryptic choice of conspecific sperm controlled by the impact of ovarian fluid on sperm swimming behavior.Evolution; international journal of organic evolution · 2013Article
- 100 years of sperm chemotaxis.The Journal of general physiology · 2012Article
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Authors and funding
8 authors.
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Abstract
Sperm, navigating in a chemical gradient, are exposed to a periodic stream of chemoattractant molecules. The periodic stimulation entrains Ca(2+) oscillations that control looping steering responses. It is not known how sperm sample chemoattractant molecules during periodic stimulation and adjust their sensitivity. We report that sea urchin sperm sampled molecules for 0.2-0.6 s before a Ca(2+) response was produced. Additional molecules delivered during a Ca(2+) response reset the cell by causing a pronounced Ca(2+) drop that terminated the response; this reset was followed by a new Ca(2+) rise. After stimulation, sperm adapted their sensitivity following the Weber-Fechner law. Taking into account the single-molecule sensitivity, we estimate that sperm can register a minimal gradient of 0.8 fM/µm and be attracted from as far away as 4.7 mm. Many microorganisms sense stimulus gradients along periodic paths to translate a spatial distribution of the stimulus into a temporal pattern of the cell response. Orchestration of temporal sampling, resetting, and adaptation might control gradient sensing in such organisms as well.
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