Evidence map›Paper›PMID 22986407›Full record

ArticleBioarchitecture

How a common variant in the growth factor receptor gene, NTRK1, affects white matter.

Meredith N Braskie, Neda Jahanshad, Arthur W Toga, Katie L McMahon, Greig I de Zubicaray, Nicholas G Martin, Margaret J Wright, Paul M Thompson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioarchitecture. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Meredith N BraskieImaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
Neda JahanshadImaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
Arthur W TogaImaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
Katie L McMahonCentre for Advanced Imaging; University of Queensland; Brisbane, QLD Australia.
Greig I de ZubicaraySchool of Psychology; University of Queensland; Brisbane, QLD Australia.
Nicholas G MartinQueensland Institute of Medical Research; Brisbane, QLD Australia.
Margaret J WrightQueensland Institute of Medical Research; Brisbane, QLD Australia.
Paul M ThompsonImaging Genetics Center at the Laboratory of Neuro Imaging; Department of Neurology; UCLA School of Medicine; Los Angeles, CA USA.
Imaging Center · USBrisbane School of Theology · AUQIMR Berghofer Medical Research Institute · AUUCLA Health · US

Funding

UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BREDESEN, DALE E. · 1999 to 2014
$25.9M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
Genetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
A Multidimensional Alzheimer's Disease Brain AtlasR01EB008281 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.4M
Computational Modeling of High-Field MR ImagesR01EB007813 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.3M
NIA NIH HHS AG040060NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG-16570NIA NIH HHS R01 AG040060NIBIB NIH HHS EB007813NIBIB NIH HHS EB008281NIBIB NIH HHS EB008432NIBIB NIH HHS R01 EB007813NIBIB NIH HHS R01 EB008281NIBIB NIH HHS R01 EB008432NICHD NIH HHS R01 HD050735
6 · The paper itself

Abstract

Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated in a number of mental illnesses. Recently, we reported that healthy young adults who carry the T allele variant in the growth factor gene, NTRK1 (at location rs6336), had lower white matter integrity than non-carriers on diffusion images of the brain. Diffusion tensor imaging (DTI) revealed how this single nucleotide polymorphism affects white matter microstructure in human populations; DTI is also used to identify characteristic features of brain connectivity in typically developing children and in patients. Newly discovered links between neuroimaging measures and growth factors whose molecular neuroscience is well known offer an important step in understanding mechanisms that contribute to brain connectivity. Altered fiber connectivity may mediate the relationship between some genetic risk factors and a variety of mental illnesses.

Indexed as

Genetic VariationHumansLeukoencephalopathiesReceptor, trkAWhite MatterReceptor, trkAdevelopmentdiffusion tensor imagingfractional anisotropygrowth factormyelinneurotrophic tyrosine kinase receptor 1neurotrophinradial diffusivityschizophreniatropomyosin-related kinase receptor A

Identifiers

PMID22986407
PMCPMC3696063
OpenAlexW1990510528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.