ArticleNeuroscience2012
Repeated restraint stress increases basolateral amygdala neuronal activity in an age-dependent manner.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Mild environmental stress inoculation promotes resilience to anxiety in female rats.Scientific reports · 2025Article
- Implicating neuroinflammation in hippocampus, prefrontal cortex and amygdala with cognitive deficit: a narrative review.3 Biotech · 2025Review
- Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat.BMC neuroscience · 2025Article
- Effects of repeated social stress on risk assessment behaviors and response to diazepam in the elevated plus maze in adult male rats.Behavioral neuroscience · 2025Article
- Prenatal methadone exposure produces functional and molecular alterations in the basolateral amygdala and decreased voluntary ethanol intake in female, but not male offspring.Frontiers in behavioral neuroscience · 2025Article
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- Sex- and exposure age-dependent effects of adolescent stress on ventral tegmental area dopamine system and its afferent regulators.Molecular psychiatry · 2023Article
- Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and across the Estrous Cycle.Neuroendocrinology · 2023Article
- A central amygdala input to the dorsal vagal complex controls gastric motility in mice under restraint stress.Frontiers in physiology · 2023Article
- Know thy SEFL: Fear sensitization and its relevance to stressor-related disorders.Neuroscience and biobehavioral reviews · 2022Review
- New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder.International journal of molecular sciences · 2022Review
- Medial orbitofrontal cortex and nucleus accumbens mediation in risk assessment behaviors in adolescents and adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Rodent models of stress and dendritic plasticity - Implications for psychopathology.Neurobiology of stress · 2022Article
- Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala.iScience · 2022Article
- Shifts in Medial Orbitofrontal Cortex Activity from Adolescence to Adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice.Frontiers in behavioral neuroscience · 2022Article
- Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway.Molecular psychiatry · 2021Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Stress impacts corticoamygdalar connectivity in an age-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Amygdala Allostasis and Early Life Adversity: Considering Excitotoxicity and Inescapability in the Sequelae of Stress.Frontiers in human neuroscience · 2021Article
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Authors and funding
2 authors.
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Abstract
Chronic stress is a precipitating factor for affective disorders such as depression and anxiety. This is associated with the effects of chronic stress on the amygdala. Adolescents may be more vulnerable to the effects of chronic stress, which may be related to its impact on amygdala function. However, the stress-induced changes in amygdala neuronal activity, and the age-dependent impact of chronic stress on amygdala neuronal activity have not been studied in depth. In this study, we investigated how repeated restraint impacts basolateral amygdala (BLA) projection neuron activity in both adolescent and adult rats. Using in vivo extracellular recordings from anesthetized rats, we found that repeated restraint increased the number of spontaneously firing neurons in the BLA of adolescent rats, but did not significantly increase the firing rate. In contrast, repeated restraint increased the firing rate of BLA neurons in adult rats, but did not change the number of spontaneously firing neurons. This is the first direct evidence of how stress differently impacts amygdala physiology in adolescent and adult rats. These findings may shed light on the mechanism by which chronic stress may age-dependently precipitate psychiatric disorders.
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