ArticleTraffic (Copenhagen, Denmark)2012
A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization.
Article in Traffic (Copenhagen, Denmark), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.Nature communications · 2019Article
- Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle.Molecular biology of the cell · 2019Article
- Modulation of alternative splicing of trafficking genes by genome editing reveals functional consequences in muscle biology.The international journal of biochemistry & cell biology · 2018Article
- Review
- Listeriolysin O-dependent host surfaceome remodeling modulates Listeria monocytogenes invasion.Pathogens and disease · 2018Article
- Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis.Nature reviews. Microbiology · 2018Review
- Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia.Seminars in cell & developmental biology · 2016Review
- Clathrin light chains' role in selective endocytosis influences antibody isotype switching.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Flat clathrin lattices: stable features of the plasma membrane.Molecular biology of the cell · 2014Article
- Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.Cold Spring Harbor perspectives in biology · 2014Review
- Role of host GTPases in infection by Listeria monocytogenes.Cellular microbiology · 2014Review
- Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration.Nature communications · 2014Article
- Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization.The Journal of cell biology · 2014Article
- Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.Cold Spring Harbor perspectives in biology · 2014Review
- Article
- Identification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screening.PLoS pathogens · 2014Article
- The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread.Nature reviews. Microbiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Invasive bacterial pathogens often target cellular proteins involved in adhesion as a first event during infection. For example, Listeria monocytogenes uses the bacterial protein InlA to interact with E-cadherin, hijack the host adherens junction (AJ) machinery and invade non-phagocytic cells by a clathrin-dependent mechanism. Here, we investigate a potential role for clathrin in cell-cell adhesion. We observed that the initial steps of AJ formation trigger the phosphorylation of clathrin, and its transient localization at forming cell-cell contacts. Furthermore, we show that clathrin serves as a hub for the recruitment of proteins that are necessary for the actin rearrangements that accompany the maturation of AJs. Using an InlA/E-cadherin chimera, we show that adherent cells expressing the chimera form AJs with cells expressing E-cadherin. We demonstrate that non-adherent cells expressing the InlA chimera, as bacteria, can be internalized by E-cadherin-expressing adherent cells. Together these results reveal that a common clathrin-mediated machinery may regulate internalization and cell adhesion and that the relative mobility of one of the interacting partners plays an important role in the commitment to either one of these processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.