ArticleBMC medical research methodology2012
Longitudinal beta regression models for analyzing health-related quality of life scores over time.
Article in BMC medical research methodology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- A prospective cohort study on longitudinal trajectories of cognitive function after stroke.Scientific reports · 2021Trial
- Cost-Effectiveness of a Comprehensive Approach for Hypertension Control in Low-Income Settings in Argentina: Trial-Based Analysis of the Hypertension Control Program in Argentina.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2018Trial
- Practice Transformation Support and Patient Engagement to Improve Cardiovascular Care: From EvidenceNOW Southwest (ENSW).Journal of the American Board of Family Medicine : JABFMTrial
- The long-term effects of drinking alcohol for stress coping on mental health symptoms among Fukushima nuclear plant workers: the Fukushima NEWS Project study.Social psychiatry and psychiatric epidemiology · 2026Article
- Level of Vegetable Commercialization and Its Determinants Among Smallholder Farmers in Northwestern Ethiopia.Food science & nutrition · 2026Article
- Predicting EQ-5D-3L utility values from clinical data in a prospective cohort of kidney transplant recipients.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Observational
- Article
- Evaluation of a Theoretical and Experiential Training Programme for Allied Healthcare Providers to Prescribe Exercise Among Persons with Multiple Sclerosis: A Co-Designed Effectiveness-Implementation Study.Journal of clinical medicine · 2025Article
- Assessing the health-state utility values of rare disease-hemophilia B using EQ-5D-5L: a study based on the Chinese population.Orphanet journal of rare diseases · 2025Article
- Socio-demographic disparities in health-related quality of life in hypertensive patients in Bangladesh: a comprehensive survey analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Assessment of Baseline Ultrawidefield Fluorescein Angiographic Quantitative Leakage Parameters with Ultrawidefield Fundus Features and Clinical Parameters in Diabetic Retinopathy in Protocol AA.Ophthalmology. Retina · 2025Observational
- Impact of mental disorders on health-related quality of life: a propensity score matched comparison.Frontiers in psychiatry · 2025Article
- Analyzing quality of life among people with opioid use disorder from the National Institute on Drug Abuse Data Share initiative: implications for decision making.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Bayesian Learning of Personalized Longitudinal Biomarker Trajectory.Annals of data science · 2024Article
- Changes in atherosclerotic cardiovascular disease risk over time among people living with HIV.The Journal of antimicrobial chemotherapy · 2024Article
- A monotone single index model for missing-at-random longitudinal proportion data.Journal of applied statistics · 2024Article
- Factors Affecting Health-Related Quality of Life in Patients With Metastatic Breast Cancer.Journal of breast cancer · 2023Article
- Health-related quality of life among patients with treated alcohol use disorders, schizophreniform disorders or affective disorders and the influence of flexible and integrative psychiatric care models in Germany (PsychCare).Frontiers in psychiatry · 2023Article
- Mapping health assessment questionnaire disability index onto EQ-5D-5L in China.Frontiers in public health · 2023Article
- Mapping the Peds QLFrontiers in public health · 2023Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundHealth-related quality of life (HRQL) has become an increasingly important outcome parameter in clinical trials and epidemiological research. HRQL scores are typically bounded at both ends of the scale and often highly skewed. Several regression techniques have been proposed to model such data in cross-sectional studies, however, methods applicable in longitudinal research are less well researched. This study examined the use of beta regression models for analyzing longitudinal HRQL data using two empirical examples with distributional features typically encountered in practice.
methodsWe used SF-6D utility data from a German older age cohort study and stroke-specific HRQL data from a randomized controlled trial. We described the conceptual differences between mixed and marginal beta regression models and compared both models to the commonly used linear mixed model in terms of overall fit and predictive accuracy.
resultsAt any measurement time, the beta distribution fitted the SF-6D utility data and stroke-specific HRQL data better than the normal distribution. The mixed beta model showed better likelihood-based fit statistics than the linear mixed model and respected the boundedness of the outcome variable. However, it tended to underestimate the true mean at the upper part of the distribution. Adjusted group means from marginal beta model and linear mixed model were nearly identical but differences could be observed with respect to standard errors.
conclusionsUnderstanding the conceptual differences between mixed and marginal beta regression models is important for their proper use in the analysis of longitudinal HRQL data. Beta regression fits the typical distribution of HRQL data better than linear mixed models, however, if focus is on estimating group mean scores rather than making individual predictions, the two methods might not differ substantially.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.