ArticlePloS one2012
Novel effects of hormonal contraceptive use on the plasma proteome.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Ethinylestradiol in combined hormonal contraceptive has a broader effect on serum proteome compared with estradiol valerate: a randomized controlled trial.Human reproduction (Oxford, England) · 2023Trial
- Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2015Trial
- Selenium, zinc, and copper intake and status of vegetarian, vegan, and omnivore children and adolescents: results of the VeChi youth study.European journal of nutrition · 2025Article
- The use of oral contraceptives and the risks of developing prehypertension and hypertension in women of reproductive age: findings from a population-based survey in Indonesia.BMC public health · 2025Article
- Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies.Communications medicine · 2025Article
- Multiomics Analysis of a Micronutrient-Rich Dietary Pattern and the Aging Genotype 9p21 on the Plasma Proteome of Young Adults.Nutrients · 2025Article
- Plasma Inflammatory Proteome Profile in a Cohort of Patients with Recurrent Vulvovaginal Candidiasis in Kenya.Journal of fungi (Basel, Switzerland) · 2024Article
- Oral contraceptives in adolescents: a retrospective population-based study on blood pressure and metabolic dysregulation.European journal of clinical pharmacology · 2024Article
- Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Genetic variation in 9p21, dietary patterns, and insulin sensitivity.Frontiers in genetics · 2022Article
- Plasma Carotenoids and Premenstrual Symptoms in a Multi-Ethnic Population of Young Women.Nutrients · 2021Article
- Influence of oral contraceptives on lipid profile and paraoxonase and commonly hepatic enzymes activities.Journal of clinical laboratory analysis · 2018Article
- Hormonal contraceptive use and prevalence of premenstrual symptoms in a multiethnic Canadian population.BMC women's health · 2017Article
- Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study.Nutrition & metabolism · 2015Article
- Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community.International journal of women's health · 2014Article
- Positive association between 25-hydroxyvitamin D and C-reactive protein is confounded by hormonal contraceptive use.Journal of women's health (2002) · 2013Article
- Plasma concentration of cis9trans11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study.Nutrition & metabolism · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundHormonal contraceptive (HC) use may increase cardiometabolic risk; however, the effect of HC on emerging cardiometabolic and other disease risk factors is not clear.
objectivesTo determine the association between HC use and plasma proteins involved in established and emerging disease risk pathways.
methodConcentrations of 54 high-abundance plasma proteins were measured simultaneously by LC-MRM/MS in 783 women from the Toronto Nutrigenomics and Health Study. C-reactive protein (CRP) was measured separately. ANCOVA was used to test differences in protein concentrations between users and non-users, and among HC users depending on total hormone dose. Linear regression was used to test the association between duration (years) of HC use and plasma protein concentrations. Principal components analysis (PCA) was used to identify plasma proteomic profiles in users and non-users.
resultsAfter Bonferroni correction, 19 proteins involved in inflammation, innate immunity, coagulation and blood pressure regulation were significantly different between users and non-users (P<0.0009). These differences were replicated across three distinct ethnocultural groups. Traditional markers of glucose and lipid metabolism were also significantly higher among HC users. Neither hormone dose nor duration of use affected protein concentrations. PCA identified 4 distinct proteomic profiles in users and 3 in non-users.
conclusionHC use was associated with different concentrations of plasma proteins along various disease-related pathways, and these differences were present across different ethnicities. Aside from the known effect of HC on traditional biomarkers of cardiometabolic risk, HC use also affects numerous proteins that may be biomarkers of dysregulation in inflammation, coagulation and blood pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.