ArticlePloS one2012
Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Outbreaks of post-weaning diarrhea caused by ETEC F4 are strongly associated with CHCF1 genotype in Danish pigs.Scientific reports · 2025Article
- Detection and Analysis of Antidiarrheal Genes and Immune Factors in Various Shanghai Pig Breeds.Biomolecules · 2024Article
- Effect of dietary tall oil fatty acids and hydrolysed yeast in SNP2-positive and SNP2-negative piglets challenged with F4 enterotoxigenic Escherichia coli.Scientific reports · 2024Article
- Accurate haplotype construction and detection of selection signatures enabled by high quality pig genome sequences.Nature communications · 2023Article
- Comprehensive analysis of circular RNAs in porcine small intestine epithelial cells associated with susceptibility to Escherichia coli F4ac diarrhea.BMC genomics · 2023Article
- A blend of selected botanicals maintains intestinal epithelial integrity and reduces susceptibility toFrontiers in veterinary science · 2023Article
- Post-weaning diarrhea in pigs from a single Danish production herd was not associated with the pre-weaning fecal microbiota composition and diversity.Frontiers in microbiology · 2023Article
- Evidence-Based Approaches for Determining Effective Target Antigens to Develop Vaccines against Post-Weaning Diarrhea Caused by EnterotoxigenicAnimals : an open access journal from MDPI · 2022Article
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Effects of the Administration ofFrontiers in microbiology · 2021Article
- F4- and F18-Positive Enterotoxigenic Escherichia coli Isolates from Diarrhea of Postweaning Pigs: Genomic Characterization.Applied and environmental microbiology · 2020Article
- Transcriptomic Study of Porcine Small Intestine Epithelial Cells Reveals Important Genes and Pathways Associated With Susceptibility toFrontiers in genetics · 2020Article
- Identification of porcine CTLA4 gene polymorphism and their association with piglet diarrhea and performance traits.Molecular biology reports · 2019Article
- Methodology and application ofJournal of animal science and biotechnology · 2019Review
- Piglet gut microbial shifts early in life: causes and effects.Journal of animal science and biotechnology · 2019Review
- Effect of Puerarin, Baicalin and Berberine Hydrochloride on the Regulation of IPEC-J2 Cells Infected with EnterotoxigenicEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Assessment of Autozygosity Derived From Runs of Homozygosity in Jinhua Pigs Disclosed by Sequencing Data.Frontiers in genetics · 2019Article
- Effect of mucin 4 allele on susceptibility to experimental infection with enterotoxigenic F4Journal of animal science and biotechnology · 2019Article
- Development of a pig infection model with colistin-resistant Escherichia coli.Veterinary microbiology · 2018Article
- Antimicrobial resistance in livestock: advances and alternatives to antibiotics.Animal frontiers : the review magazine of animal agriculture · 2018Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterotoxigenic Escherichia coli (ETEC) F4ac is a major determinant of diarrhea and mortality in neonatal and young pigs. Susceptibility to ETEC F4ac is governed by the intestinal receptor specific for the bacterium and is inherited as a monogenic dominant trait. To identify the receptor gene (F4acR), we first mapped the locus to a 7.8-cM region on pig chromosome 13 using a genome scan with 194 microsatellite markers. A further scan with high density markers on chromosome 13 refined the locus to a 5.7-cM interval. Recombination breakpoint analysis defined the locus within a 2.3-Mb region. Further genome-wide mapping using 39,720 informative SNPs revealed that the most significant markers were proximal to the MUC13 gene in the 2.3-Mb region. Association studies in a collection of diverse outbred populations strongly supported that MUC13 is the most likely responsible gene. We characterized the porcine MUC13 gene that encodes two transcripts: MUC13A and MUC13B. Both transcripts have the characteristic PTS regions of mucins that are enriched in distinct tandem repeats. MUC13B is predicated to be heavily O-glycosylated, forming the binding site of the bacterium; while MUC13A does not have the O-glycosylation binding site. Concordantly, 127 independent pigs homozygous for MUC13A across diverse breeds are all resistant to ETEC F4ac, and all 718 susceptible animals from the broad breed panel carry at least one MUC13B allele. Altogether, we conclude that susceptibility towards ETEC F4ac is governed by the MUC13 gene in pigs. The finding has an immediate translation into breeding practice, as it allows us to establish an efficient and accurate diagnostic test for selecting against susceptible animals. Moreover, the finding improves our understanding of mucins that play crucial roles in defense against enteric pathogens. It revealed, for the first time, the direct interaction between MUC13 and enteric bacteria, which is poorly understood in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.