ArticlePloS one2012
Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- Integrative transcriptomics-metabolomics reveals sphingolipid metabolic reprogramming in traditional Chinese medicine syndrome differentiation of rheumatoid arthritis.Frontiers in immunology · 2026Article
- Metabolomics: A Viable Approach to Understand the Pathogenesis of Reactive ArthritisEndocrine, metabolic & immune disorders drug targets · 2026Review
- Application of metabolomics in the classification of traditional Chinese medicine syndromes in rheumatoid arthritis.Clinical rheumatology · 2025Article
- Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study.Journal of oral microbiology · 2024Article
- Comparative Metabolomic Profiles of Vascular Involvement in Behçet's Disease.European journal of rheumatology · 2023Article
- Rheumatoid arthritis characteristics and classification of heat and cold patterns-an observational study.Heliyon · 2023Article
- Big Data in Gastroenterology Research.International journal of molecular sciences · 2023Review
- Developing a Personalized Integrative Obesity-Coaching Program: A Systems Health Perspective.International journal of environmental research and public health · 2022Article
- ReDisX, a machine learning approach, rationalizes rheumatoid arthritis and coronary artery disease patients uniquely upon identifying subpopulation differentiation markers from their genomic data.Frontiers in medicine · 2022Article
- NMR-based serum and muscle metabolomics for diagnosis and activity assessment in idiopathic inflammatory myopathies.Analytical science advances · 2021Article
- Metabolomics profiling predicts outcome of tocilizumab in rheumatoid arthritis: an exploratory study.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients.Frontiers in immunology · 2020Article
- Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS andEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Metabolomic Analysis of Biochemical Changes in the Serum and Urine of Freund's Adjuvant-Induced Arthritis in Rats after Treatment with Silkworm Excrement.Molecules (Basel, Switzerland) · 2018Article
- Metabolomic profile of systemic sclerosis patients.Scientific reports · 2018Article
- Understanding Chinese Medicine Patterns of Rheumatoid Arthritis and Related Biomarkers.Medicines (Basel, Switzerland) · 2018Review
- Prediction of cold and heat patterns using anthropometric measures based on machine learning.Chinese journal of integrative medicine · 2018Article
- Urinary Metabolomic Profiling to Identify Potential Biomarkers for the Diagnosis of Behcet's Disease by Gas Chromatography/Time-of-Flight-Mass Spectrometry.International journal of molecular sciences · 2017Article
- Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern.International journal of molecular sciences · 2016Article
- NMR based serum metabolomics reveals a distinctive signature in patients with Lupus Nephritis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim is to characterize subgroups or phenotypes of rheumatoid arthritis (RA) patients using a systems biology approach. The discovery of subtypes of rheumatoid arthritis patients is an essential research area for the improvement of response to therapy and the development of personalized medicine strategies.
methodsIn this study, 39 RA patients are phenotyped using clinical chemistry measurements, urine and plasma metabolomics analysis and symptom profiles. In addition, a Chinese medicine expert classified each RA patient as a Cold or Heat type according to Chinese medicine theory. Multivariate data analysis techniques are employed to detect and validate biochemical and symptom relationships with the classification.
resultsThe questionnaire items 'Red joints', 'Swollen joints', 'Warm joints' suggest differences in the level of inflammation between the groups although c-reactive protein (CRP) and rheumatoid factor (RHF) levels were equal. Multivariate analysis of the urine metabolomics data revealed that the levels of 11 acylcarnitines were lower in the Cold RA than in the Heat RA patients, suggesting differences in muscle breakdown. Additionally, higher dehydroepiandrosterone sulfate (DHEAS) levels in Heat patients compared to Cold patients were found suggesting that the Cold RA group has a more suppressed hypothalamic-pituitary-adrenal (HPA) axis function.
conclusionSignificant and relevant biochemical differences are found between Cold and Heat RA patients. Differences in immune function, HPA axis involvement and muscle breakdown point towards opportunities to tailor disease management strategies to each of the subgroups RA patient.
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