Trial reportAnnals of the rheumatic diseases2013
Application of the 2010 ACR/EULAR classification criteria in patients with very early inflammatory arthritis: analysis of sensitivity, specificity and predictive values in the SAVE study cohort.
Trial report in Annals of the rheumatic diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Azilsartan as "Add-On" Treatment with Methotrexate Improves the Disease Activity of Rheumatoid Arthritis.BioMed research international · 2018Trial
- Refining serological scores in rheumatoid arthritis classification: an international study.RMD open · 2026Article
- Comparison of agreement between three classification criteria for early rheumatoid arthritis (ERA) in Shanxi Province of China.Clinical rheumatology · 2026Article
- Late-onset rheumatoid arthritis: clinical features, diagnostic challenges, and treatment approaches.Rheumatology international · 2025Review
- Predicting rheumatoid arthritis progression from seronegative undifferentiated arthritis using machine learning: a deep learning model trained on the KURAMA cohort and externally validated with the ANSWER cohort.Arthritis research & therapy · 2025Article
- Improving the performance and interpretability on medical datasets using graphical ensemble feature selection.Bioinformatics (Oxford, England) · 2024Article
- Article
- Testing for isotypes does not help differentiating rheumatoid arthritis from other rheumatoid factor positive diseases.Immunologic research · 2023Article
- Distinction and prognosis of early arthritis phenotypes: an analysis in three European cohorts.RMD open · 2023Article
- Rheumatoid Arthritis from Easy to Complex Disease: From the "2022 GISEA International Symposium".Journal of clinical medicine · 2023Review
- Impact of autoimmune serology test results on RA classification and diagnosis.Journal of translational autoimmunity · 2022Article
- Differentiating between UCTD and early-stage SLE: from definitions to clinical approach.Nature reviews. Rheumatology · 2022Review
- [Multicenter performance of the different classification criteria for rheumatoid arthritis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- MR and ultrasound of the hands and wrists in rheumatoid arthritis. Part II. Added clinical value.Skeletal radiology · 2019Review
- Comparison of Adults With Polyarticular Juvenile Idiopathic Arthritis to Adults With Rheumatoid Arthritis: A Cross-sectional Analysis of Clinical Features and Medication Use.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2019Article
- Azilsartan improves the effects of etanercept in patients with active rheumatoid arthritis: a pilot study.Therapeutics and clinical risk management · 2018Article
- Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Diagnostic spectrum and 2-year outcome in a cohort of patients with very early arthritis.RMD open · 2017Article
- Article
- Comparison of three classification criteria of rheumatoid arthritis in an inception early arthritis cohort.Clinical rheumatology · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePerformance of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria was analysed in an internationally recruited early arthritis cohort (≤16 weeks symptom duration) enrolled in the 'Stop-Arthritis-Very-Early' trial. This sample includes patients with a variety of diseases diagnosed during follow-up.
methodsTwo endpoints were defined: Investigators' diagnosis and disease-modifying antirheumatic drug (DMARD) treatment start during the 12-month follow-up. The 2010 criteria were applied to score Patients' baseline data. Sensitivity, specificity, predictive values and areas under the receiver operating curves of this scoring with respect to both endpoints were calculated and compared to the 1987 criteria. The optimum level of agreement between the endpoints and the 2010 classification score ways estimated by Cohen's ϰ coefficients.
results303 patients had 12-months follow-up. Positive predictive values of the 2010 criteria were 0.68 and 0.71 for RA-diagnosis and DMARD-start, respectively. Sensitivity for RA-diagnosis was 0.85, for DMARD-start 0.8, whereas the 1987 criteria's sensitivities were 0.65 and 0.55. The areas under the receiver operating curves of the 2010 criteria for RA-diagnosis and DMARD-start were 0.83 and 0.78. Analysis of inter-rater-agreement using Cohen's ϰ demonstrated the highest ϰ values (0.5 for RA-diagnosis and 0.43 for DMARD-start) for the score of 6.
conclusionsIn this international very early arthritis cohort predictive and discriminative abilities of the 2010 ACR/EULAR classification criteria were satisfactory and substantially superior to the 'old' 1987 classification criteria. This easier classification of RA in early stages will allow targeting truly early disease stages with appropriate therapy.
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