ReviewMolecular neurobiology2013
Microdomains in forebrain spines: an ultrastructural perspective.
Review in Molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Selective alterations in CA1 spine morphology following dietary fructose intake.Brain structure & function · 2026Article
- Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree.BMC psychiatry · 2025Article
- Article
- Review
- The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.Scientific reports · 2021Article
- Distribution of cortactin in cerebellar Purkinje cell spines.Scientific reports · 2021Article
- F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes.The EMBO journal · 2019Article
- Interrogating Synaptic Architecture: Approaches for Labeling Organelles and Cytoskeleton Components.Frontiers in synaptic neuroscience · 2019Review
- α4βδ-GABAJournal of neuroscience research · 2018Article
- The Actin Cytoskeleton and Actin-Based Motility.Cold Spring Harbor perspectives in biology · 2018Review
- The Emerging Role of Mechanics in Synapse Formation and Plasticity.Frontiers in cellular neuroscience · 2018Review
- The Diversity of Spine Synapses in Animals.Neuromolecular medicine · 2016Review
- Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.Cellular and molecular life sciences : CMLS · 2016Review
- Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation.The Journal of cell biology · 2015Article
- Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB.Journal of neurochemistry · 2015Article
- FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons.Frontiers in neuroanatomy · 2015Article
- Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.The EMBO journal · 2014Article
- α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia.Neuroscience · 2014Article
- Learning improvement after PI3K activation correlates with de novo formation of functional small spines.Frontiers in molecular neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Glutamatergic axons in the mammalian forebrain terminate predominantly onto dendritic spines. Long-term changes in the efficacy of these excitatory synapses are tightly coupled to changes in spine morphology. The reorganization of the actin cytoskeleton underlying this spine "morphing" involves numerous proteins that provide the machinery needed for adaptive cytoskeletal remodeling. Here, we review recent literature addressing the chemical architecture of the spine, focusing mainly on actin-binding proteins (ABPs). Accumulating evidence suggests that ABPs are organized into functionally distinct microdomains within the spine cytoplasm. This functional compartmentalization provides a structural basis for regulation of the spinoskeleton, offering a novel window into mechanisms underlying synaptic plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.