Evidence map›Paper›PMID 22983843›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2012

Chemopreventive properties of dietary rice bran: current status and future prospects.

Angela J Henderson, Cadie A Ollila, Ajay Kumar, Erica C Borresen, Komal Raina, Rajesh Agarwal, Elizabeth P Ryan

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05101421 (The Effects of Rice Ceramide Supplementation in Improving Skin Health), which is not on this map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05101421 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Rice Ceramide Supplementation in Improving Skin Health

TypeinterventionalSponsorNexus Wise Sdn BhdRan2021 to 2022Enrolled50ConditionsSkin ConditionArmsRice ceramide supplementation
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 218 citations in OpenAlex.

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  8. Evaluation of the trade-off between variety, processing, and low-GI claim in ready-to-eat rice.Food science and technology international = Ciencia y tecnologia de los alimentos internacional · 2026
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Angela J HendersonDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
Cadie A Ollila
Ajay Kumar
Erica C Borresen
Komal Raina
Rajesh Agarwal
Elizabeth P Ryan
Colorado State University · USUniversity of Colorado Boulder · USUniversity of Montana · US

Funding

Colon Cancer Chemoprevention by Flavonoid SilibininR01CA112304 · NCI · UNIVERSITY OF COLORADO DENVER · PI AGARWAL, RAJESH · 2005 to 2015
$2.9M
Probiotic Metabolism of Rice Bran Phytochemicals for ChemopreventionR03CA150070 · NCI · COLORADO STATE UNIVERSITY · PI RYAN, ELIZABETH P · 2010 to 2011
$145k
NCI NIH HHS CA112304NCI NIH HHS R01 CA112304NCI NIH HHS R03 CA150070NCI NIH HHS R03CA150070
6 · The paper itself

Abstract

Emerging evidence suggests that dietary rice bran may exert beneficial effects against several types of cancer, such as breast, lung, liver, and colorectal cancer. The chemopreventive potential has been related to the bioactive phytochemicals present in the bran portion of the rice such as ferulic acid, tricin, β-sitosterol, γ-oryzanol, tocotrienols/tocopherols, and phytic acid. Studies have shown that the anticancer effects of the rice bran-derived bioactive components are mediated through their ability to induce apoptosis, inhibit cell proliferation, and alter cell cycle progression in malignant cells. Rice bran bioactive components protect against tissue damage through the scavenging of free radicals and the blocking of chronic inflammatory responses. Rice bran phytochemicals have also been shown to activate anticancer immune responses as well as affecting the colonic tumor microenvironment in favor of enhanced colorectal cancer chemoprevention. This is accomplished through the modulation of gut microflora communities and the regulation of carcinogen-metabolizing enzymes. In addition, the low cost of rice production and the accessibility of rice bran make it an appealing candidate for global dietary chemoprevention. Therefore, the establishment of dietary rice bran as a practical food-derived chemopreventive agent has the potential to have a significant impact on cancer prevention for the global population.

Indexed as

DietPhytotherapyAntineoplastic Agents, PhytogenicColorectal NeoplasmsHumansNeoplasmsOryzaPlant PreparationsSeedsAntineoplastic Agents, PhytogenicPlant Preparations

Identifiers

PMID22983843
PMCPMC3648746
OpenAlexW2096760268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.