Evidence map›Paper›PMID 22983778›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2012

Temporary elimination of orthostatic hypotension by norepinephrine infusion.

David S Goldstein, LaToya Sewell, Courtney Holmes, Sandra Pechnik, André Diedrich, David Robertson

Registry-linked trialOpen access · greenAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01285908 (Safety and Efficacy of Intravenous Norepinephrine for Orthostatic Hypotension), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01285908 phase1 / phase2completednot on this map

Safety and Efficacy of Intravenous Norepinephrine for Orthostatic Hypotension

TypeinterventionalSponsorNational Institute of Neurological Disorders and Stroke (NINDS)Ran2011 to 2012Enrolled6ConditionsOrthostatic HypertensionArmsIntravenous Norepinephrine Infusion
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Homeostatic systems, biocybernetics, and autonomic neuroscience.Autonomic neuroscience : basic & clinical · 2017
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

David S GoldsteinClinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1620, USA. goldsteind@ninds.nih.gov
LaToya Sewell
Courtney Holmes
Sandra Pechnik
André Diedrich
David Robertson
National Institutes of Health · USVanderbilt University · USNational Institute of Neurological Disorders and Stroke · US

Funding

Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 1997 to 2016
$30.8M
Treatment of Catecholaminergic NeurodegenerationZIANS003125 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2011 to 2022
$3.2M
Intramural NIH HHS ZIA NS003125NHLBI NIH HHS P01 HL056693
6 · The paper itself

Abstract

A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a "prosthetic baroreceptor system" to maintain blood pressure during orthostasis without worsening supine hypertension. In all of four patients with neurogenic OH, titrated i.v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH.

Indexed as

Blood PressureHumansHypotension, OrthostaticInfusions, Intra-ArterialNorepinephrineParkinson DiseasePure Autonomic FailureTilt-Table TestTreatment OutcomeVasoconstrictor AgentsNorepinephrineVasoconstrictor Agents

Identifiers

PMID22983778
PMCPMC4118053
OpenAlexW2005071390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.