Evidence map›Paper›PMID 22983555›Full record

ArticleThe EMBO journal2012

Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.

Adrian Kee Keong Teo, Rohit N Kulkarni

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Frontiers in medicine · 2023
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adrian Kee Keong TeoSection of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rohit N Kulkarni
Brigham and Women's Hospital · US

Funding

Role of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0M
Search for new MODY genes and molecular studies of their function in beta cellsR01DK055523 · NIDDK · JOSLIN DIABETES CENTER · PI DORIA, ALESSANDRO, KULKARNI, ROHIT N. · 1998 to 2014
$4.0M
NIDDK NIH HHS R01 DK055523NIDDK NIH HHS R01 DK067536NIDDK NIH HHS R01 DK 55523NIDDK NIH HHS R01 DK 67536
6 · The paper itself

Abstract

Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.

Indexed as

A Kinase Anchor ProteinsAnimalsGlucoseHomeostasisInsulin ResistanceMaleMembrane ProteinsPhosphoprotein PhosphatasesAkap5 protein, mouseA Kinase Anchor ProteinsGlucoseMembrane ProteinsPhosphoprotein Phosphatases

Identifiers

PMID22983555
PMCPMC3474931
OpenAlexW1515082172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.