ArticleLab on a chip2012
Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Development of a DNA Aptamer-Based Approach to Noninvasively Image CAR-T Cells In Vivo and Traceless Enrichment In Vitro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Facile, rapid and efficient isolation of circulating tumor cells using aptamer-targeted magnetic nanoparticles integrated with a microfluidic device.RSC advances · 2022Article
- Three step flow focusing enables image-based discrimination and sorting of late stage 1 Haematococcus pluvialis cells.PloS one · 2021Article
- Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials.Sensors (Basel, Switzerland) · 2020Review
- Immunomagnetic separation of circulating tumor cells with microfluidic chips and their clinical applications.Biomicrofluidics · 2020Review
- Aptamers as Reversible Sorting Ligands for Preparation of Cells in Their Native State.Cell chemical biology · 2020Article
- Simulation of circulating tumor cell transport and adhesion in cell suspensions in microfluidic devices.Biomicrofluidics · 2019Article
- Traceless aptamer-mediated isolation of CD8Nature biomedical engineering · 2019Article
- Efficient release of immunocaptured cells using coiled-coils in a microfluidic device.RSC advances · 2019Article
- Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells.Oncology letters · 2019Article
- Programmable hydrogels.Biomaterials · 2018Review
- Numerical simulation of cell squeezing through a micropore by the immersed boundary method.Proceedings of the Institution of Mechanical Engineers. Part C. Journal of mechanical engineering science · 2018Article
- Aptamers and Glioblastoma: Their Potential Use for Imaging and Therapeutic Applications.International journal of molecular sciences · 2017Review
- Strategies in Ebola virus disease (EVD) diagnostics at the point of care.Critical reviews in microbiology · 2017Review
- Circulating tumor cell detection: A direct comparison between negative and unbiased enrichment in lung cancer.Oncology letters · 2017Article
- Enrichment and single-cell analysis of circulating tumor cells.Chemical science · 2017Article
- Aptamer-conjugated live human immune cell based biosensors for the accurate detection of C-reactive protein.Scientific reports · 2016Article
- Effect of graphene oxide ratio on the cell adhesion and growth behavior on a graphene oxide-coated silicon substrate.Scientific reports · 2016Article
- Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement.Scientific reports · 2016Article
- Oligonucleotide aptamers: A next-generation technology for the capture and detection of circulating tumor cells.Methods (San Diego, Calif.) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Early detection and isolation of circulating tumor cells (CTC) can enable better prognosis for cancer patients. A Hele-Shaw device with aptamer functionalized glass beads is designed, modeled, and fabricated to efficiently isolate cancer cells from a cellular mixture. The glass beads are functionalized with anti-epidermal growth factor receptor (EGFR) aptamer and sit in ordered array of pits in polydimethylsiloxane (PDMS) channel. A PDMS encapsulation is then used to cover the channel and to flow through cell solution. The beads capture cancer cells from flowing solution depicting high selectivity. The cell-bound glass beads are then re-suspended from the device surface followed by the release of 92% cells from glass beads using combination of soft shaking and anti-sense RNA. This approach ensures that the cells remain in native state and undisturbed during capture, isolation and elution for post-analysis. The use of highly selective anti-EGFR aptamer with the glass beads in an array and subsequent release of cells with antisense molecules provide multiple levels of binding and release opportunities that can help in defining new classes of CTC enumeration devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.