Evidence map›Paper›PMID 22983386›Full record

SynthesisThe American journal of psychiatry2012

Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies.

Samuele Cortese, Clare Kelly, Camille Chabernaud, Erika Proal, Adriana Di Martino, Michael P Milham, F Xavier Castellanos

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 489 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
489citing papers in PubMed, 21 pooled it
35.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

489 citing papers in PubMed, 21 syntheses or guidelines pooled it, 1,043 citations in OpenAlex.

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  17. Event-related brain oscillations in attention-deficit/hyperactivity disorder (ADHD): A systematic review and meta-analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022
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429 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Samuele CortesePhyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, Child Study Center of the NYU Langone Medical Center, New York, USA.
Clare Kelly
Camille Chabernaud
Erika Proal
Adriana Di Martino
Michael P Milham
F Xavier Castellanos
University of Verona · IT

Funding

Neural Dissection of Hyperactivity/Inattention in AutismR01HD065282 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2009 to 2010
$2.3M
Functional and Structural Connectivity in Adult Attention Deficit Hyperactivity DR01MH083246 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2009 to 2011
$1.7M
Neural Substrates of Variability in Attention Deficit Hyperactivity Disorder (ADHR01MH081218 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2008 to 2010
$1.7M
NICHD NIH HHS HD065282NICHD NIH HHS R01 HD065282NIMH NIH HHS MH081218NIMH NIH HHS MH083246NIMH NIH HHS R01 MH081218NIMH NIH HHS R01 MH083246PHS HHS K23M087770
6 · The paper itself

Abstract

objectiveThe authors performed a comprehensive meta-analysis of task-based functional MRI studies of attention deficit hyperactivity disorder (ADHD).

methodThe authors searched PubMed, Ovid, EMBASE, Web of Science, ERIC, CINAHAL, and NeuroSynth for studies published through June 30, 2011. Significant differences in brain region activation between individuals with ADHD and comparison subjects were detected using activation likelihood estimation meta-analysis. Dysfunctional regions in ADHD were related to seven reference neuronal systems. The authors performed a set of meta-analyses focused on age groups (children and adults), clinical characteristics (history of stimulant treatment and presence of psychiatric comorbidities), and specific neuropsychological tasks (inhibition, working memory, and vigilance/attention).

resultsFifty-five studies were included (39 for children and 16 for adults). In children, hypoactivation in ADHD relative to comparison subjects was observed mostly in systems involved in executive function (frontoparietal network) and attention (ventral attentional network). Significant hyperactivation in ADHD relative to comparison subjects was observed predominantly in the default, ventral attention, and somatomotor networks. In adults, ADHD-related hypoactivation was predominant in the frontoparietal system, while ADHD-related hyperactivation was present in the visual, dorsal attention, and default networks. Significant ADHD-related dysfunction largely reflected task features and was detected even in the absence of comorbid mental disorders or a history of stimulant treatment.

conclusionsA growing literature provides evidence of ADHD-related dysfunction in multiple neuronal systems involved in higher-level cognitive functions but also in sensorimotor processes, including the visual system, and in the default network. This meta-analytic evidence extends early models of ADHD pathophysiology that were focused on prefrontal-striatal circuits.

Indexed as

Attention Deficit Disorder with HyperactivityBrainCase-Control StudiesFunctional NeuroimagingHumansMagnetic Resonance ImagingNeural PathwaysNeuropsychological Tests

Identifiers

PMID22983386
PMCPMC3879048
OpenAlexW2137884776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.