ReviewCold Spring Harbor perspectives in medicine2012
Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal network function.
Review in Cold Spring Harbor perspectives in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178899 (Designing a Smoking Intervention for Youth Smokers Using Q-Methodology), which is not on this map. Cited by 149 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Designing a Smoking Intervention for Youth Smokers Using Q-Methodology: A Pilot Randomized Controlled Trial
Who cites it
149 citing papers in PubMed, 4 syntheses or guidelines pooled it, 290 citations in OpenAlex.
- Global prevalence of E-cigarette use among students: Systematic review and meta-analysis.PloS one · 2025Pooled it
- Association of Non-Tobacco Products (NTP) with Oral, Esophageal, and Pharyngeal Cancer and Oral Potentially Malignant Disorders (OPMD) in Adults: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Association between electronic cigarette use and tobacco cigarette smoking initiation in adolescents: a systematic review and meta-analysis.BMC public health · 2021Pooled it
- Pathway from Exposure to an E-Cigarette Prevention Social Media Campaign to Increased Quitting Intentions: A Randomized Trial Among Young Adult E-Cigarette Users.International journal of environmental research and public health · 2025Trial
- Oxytocin modulates local topography of human functional connectome in healthy men at rest.Communications biology · 2021Trial
- Association of Daily E-Cigarette Use Duration With Anxiety in Adolescents: A Comparison With Cigarette-Only and Dual Use.Psychiatry investigation · 2026Article
- Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.Psychopharmacology · 2026Article
- Narrative Review of Novel Nicotine-Delivery Systems and Emerging Pharmaceuticals for Tobacco Cessation.Medicines (Basel, Switzerland) · 2026Review
- From safer alternative to public health crisis: the unintended consequences of e-cigarettes.Annals of medicine and surgery (2012) · 2026Article
- Psychophysiological Responses in Virtual Reality for Assessing Current Nicotine Use and Future Addiction Risk Among Young Adults: Protocol for a Mixed Methods Study.JMIR research protocols · 2026Article
- Health warnings for electronic cigarette packaging: a rapid scoping review.BMC public health · 2026Article
- Motivational Drivers for Teachers as Informal Health Educators to Initiate In-Class Discussions With Adolescents About Smoking: Moderated Mediation Study Using Attribution Theory.JMIR pediatrics and parenting · 2026Article
- Adapting and Implementing a School-Based "Implementation Intentions" Program Within FRESHAIR4Life to Prevent Smoking Initiation Among Adolescents in Greece: A Study Protocol.Healthcare (Basel, Switzerland) · 2026Article
- MC-100093, a synthetic beta-lactam compound, and ceftriaxone modulate nicotine consumption, neuroinflammation and glutamatergic transporters in a nicotine self-administration mouse model.Psychopharmacology · 2026Article
- Article
- Young Adult Substance Use as a Predictor of Poor Self-Rated Memory Decades Later in Midlife.Journal of aging and health · 2026Article
- New teenage challenge: vaping and pregnancy.Frontiers in medicine · 2026Article
- Single-cell profiling of H3K4me1-H3K27me3 revealed bivalent regulation of abnormal neuronal development caused by prenatal e-cigarette vaporing.Communications biology · 2025Article
- Prevalence of adolescent dual tobacco use and its associated factors: findings from a cross-sectional study.BMJ open · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
More than 70% of adolescents report to have smoked a cigarette at least once. At the adolescent stage the brain has not completed its maturation. The prefrontal cortex (PFC), the brain area responsible for executive functions and attention performance, is one of the last brain areas to mature and is still developing during adolescence. Smoking during adolescence increases the risk of developing psychiatric disorders and cognitive impairment in later life. In addition, adolescent smokers suffer from attention deficits, which aggravate with the years of smoking. Recent studies in rodents reveal the molecular changes induced by adolescent nicotine exposure that alter the functioning of synapses in the PFC and that underlie the lasting effects on cognitive function. Here we provide an overview of these recent findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.