ArticleNature cell biology2012
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
Article in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy.Metabolic brain disease · 2023Review
- Proteomic Analysis Reveals Differential Protein Expression Induced by Inhibition of Prolyl Oligopeptidase in Filarial Parasites.The protein journal · 2022Article
- Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.Human molecular genetics · 2022Article
- A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.Cell reports · 2021Article
- Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity.Cell stress & chaperones · 2018Article
- Clinical Characteristics of Wolfram Syndrome in Chinese Population and a Novel Frameshift Mutation inFrontiers in endocrinology · 2018Article
- Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors.PloS one · 2017Article
- Article
- The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.PLoS biology · 2015Article
- Multilevel control of glucose homeostasis by adenylyl cyclase 8.Diabetologia · 2015Article
- Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.Human molecular genetics · 2015Article
- Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells.Diabetologia · 2015Article
- Subcellular optogenetics - controlling signaling and single-cell behavior.Journal of cell science · 2015Review
- RETRACTION: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.Nature cell biology · 2015Article
- Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration.American journal of human genetics · 2014Article
- Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.Nature medicine · 2014Article
- Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.The Journal of biological chemistry · 2014Article
- Many faces of monogenic diabetes.Journal of diabetes investigation · 2014Review
- Wolfram syndrome iPS cells: the first human cell model of endoplasmic reticulum disease.Diabetes · 2014Article
- β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.Diabetes · 2014 · on this mapArticle
Corrections and comments
- Retraction · 2014-12-23Error in Materials · Error in Methods · Unreliable Data · Unreliable Results and/or Conclusions · · see also http://www.nature.com/ncb/journal/v17/n1/full/ncb3093.html;
- Retracted
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its role in β-cell function remains unclear. Here we provide evidence that WFS1 is essential for glucose- and glucagon-like peptide 1 (GLP-1)-stimulated cyclic AMP production and regulation of insulin biosynthesis and secretion. Stimulation with glucose causes WFS1 translocation from the ER to the plasma membrane, where it forms a complex with adenylyl cyclase 8 (AC8), an essential cAMP-generating enzyme in the β-cell that integrates glucose and GLP-1 signalling. ER stress and mutant WFS1 inhibit complex formation and activation of AC8, reducing cAMP synthesis and insulin secretion. These findings reveal that an ER-stress-related protein has a distinct role outside the ER regulating both insulin biosynthesis and secretion. The reduction of WFS1 protein on the plasma membrane during ER stress is a contributing factor for β-cell dysfunction and progression of type 2 diabetes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.