Evidence map›Paper›PMID 22982688›Full record

SynthesisThe journals of gerontology. Series A, Biological sciences and medical sciences2013

The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis.

Alain Koyama, Jacqueline O'Brien, Jennifer Weuve, Deborah Blacker, Andrea L Metti, Kristine Yaffe

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03528044 (Evaluation and Follow up of Emotional Regulation, Cognition, Impulsivity and Reward System in Obesity, and Determination of Its Biopsychosocial Risk Factors), which is not on this map. Cited by 181 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03528044 nacompletednot on this mapstarted 2017, after this paper: background citation

Evaluation and Follow up of Emotional Regulation, Cognition, Impulsivity and Reward System in Obesity, and Determination of Its Biopsychosocial Risk Factors: A Prospective Study of Obese Patients Before and After Bariatric Surgery

TypeinterventionalSponsorKoç UniversityRan2017 to 2022Enrolled50ConditionsObesity, Cognitive DisorderArmsBariatric surgery
3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  7. Theory of mind in Alzheimer's disease and amnestic mild cognitive impairment: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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  13. A Meta-Analysis of C-Reactive Protein in Patients With Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2016
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121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alain KoyamaSan Francisco VA Medical Center, 4150 Clement St., VAMC 116H, San Francisco, CA 94121, USA. alain.koyama@va.gov
Jacqueline O'Brien
Jennifer Weuve
Deborah Blacker
Andrea L Metti
Kristine Yaffe

Funding

Changes in Sleep and Cognition in Older WomenR01AG026720 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STONE, KATIE L, YAFFE, KRISTINE · 2006 to 2016
$7.5M
Predictors & Outcomes of Cognitive Trajectories in the Oldest OldK24AG031155 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2007 to 2020
$1.5M
NIA NIH HHS K24 AG 031155NIA NIH HHS R01 AG 026720
6 · The paper itself

Abstract

backgroundStudies that have investigated the association between markers of inflammation and risk of dementia are conflicting. Therefore, the researchers conducted a systematic review and meta-analysis of observational studies with the hypothesis that an increased level of peripheral proinflammatory markers would be associated with risk of all-cause dementia or Alzheimer's disease (AD).

methodsThe researchers conducted a literature search of observational studies indexed in the PubMed and PsycInfo databases. Selected studies included those with at least one peripheral inflammatory biomarker and its association with risk of all-cause dementia or AD. Random effects models were used to generate pooled hazard ratios (HRs) comparing the top versus bottom quantile of inflammatory marker level. Heterogeneity was assessed using the I (2) statistic.

resultsSeven studies were identified, combining for a total 5,717 participants, 746 cases of all-cause dementia and 565 cases of AD. An increased level of C-reactive protein was associated with a 45% increased risk of all-cause dementia (HR: 1.45; 95% CI: 1.10, 1.91). Similarly, a higher level of interleukin-6 was associated with a 32% increased risk (HR: 1.32; 95% CI: 1.06, 1.64) of all-cause dementia. For AD alone, the association with C-reactive protein was less pronounced (HR: 1.21; 95% CI: 1.03, 1.42) and interleukin-6 was not associated with risk of AD (HR: 1.06; 95% CI: 0.83, 1.35). No significant heterogeneity was found in any of the meta-analyses (I (2) = 0%-40%, p ≥ .16).

conclusionsAn increased peripheral level of inflammatory markers is associated with a modest increase in risk of all-cause dementia. Evidence for an association with risk of AD alone is limited.

Indexed as

InflammationAgedAged, 80 and overAlzheimer DiseaseBiomarkersC-Reactive ProteinData CollectionDementiaFemaleHumansInterleukin-6MaleMiddle AgedProportional Hazards ModelsRisk AssessmentRisk FactorsBiomarkersC-Reactive ProteinInterleukin-6

Identifiers

PMID22982688
PMCPMC3693673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.