ArticleDevelopmental biology2012
Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPARα-dependent ApoB suppression.Communications biology · 2026Article
- Zebrafish as a Model to Study Retinoic Acid Signaling in Development and Disease.Biomedicines · 2023Review
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- Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials.Nature reviews. Drug discovery · 2021Review
- Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions.JCI insight · 2021Article
- Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development.Hepatology (Baltimore, Md.) · 2020Article
- Mesoderm patterning by a dynamic gradient of retinoic acid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Article
- Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research.Current topics in developmental biology · 2017Review
- Article
- Review
- Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.The Journal of clinical investigation · 2016Article
- Cannabinoid receptor signaling regulates liver development and metabolism.Development (Cambridge, England) · 2016Article
- Zebrafish: an important tool for liver disease research.Gastroenterology · 2015Review
- Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse.The American journal of pathology · 2015Article
- The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.Current opinion in genetics & development · 2015Review
- Repairing quite swimmingly: advances in regenerative medicine using zebrafish.Disease models & mechanisms · 2014Review
- Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth.Developmental cell · 2014Article
- S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury.Cell reports · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Developmental signals determine organ morphology and position during embryogenesis. To discover novel modifiers of liver development, we performed a chemical genetic screen in zebrafish and identified retinoic acid as a positive regulator of hepatogenesis. Knockdown of the four RA receptors revealed that all receptors affect liver formation, however specific receptors exert differential effects. Rargb knockdown results in bilateral livers but does not impact organ size, revealing a unique role for Rargb in conferring left-right positional information. Bilateral populations of hepatoblasts are detectable in rargb morphants, indicating Rargb acts during hepatic specification to position the liver, and primitive endoderm is competent to form liver on both sides. Hearts remain at the midline and gut looping is perturbed in rargb morphants, suggesting Rargb affects lateral plate mesoderm migration. Overexpression of Bmp during somitogenesis similarly results in bilateral livers and midline hearts, and inhibition of Bmp signaling rescues the rargb morphant phenotype, indicating Rargb functions upstream of Bmp to regulate organ sidedness. Loss of rargb causes biliary and organ laterality defects as well as asplenia, paralleling symptoms of the human condition right atrial isomerism. Our findings uncover a novel role for RA in regulating organ laterality and provide an animal model of one form of human heterotaxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.