ArticleThe Journal of steroid biochemistry and molecular biology2013
1,25(OH)(2)vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C(12) skeletal muscle cells.
Article in The Journal of steroid biochemistry and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- The Role of Vitamin D in Skeletal Muscle Repair and Regeneration in Animal Models and Humans: A Systematic Review.Nutrients · 2023Pooled it
- Trial
- Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males.European journal of applied physiology · 2014Trial
- A randomized study on the effect of vitamin D₃ supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women.The Journal of clinical endocrinology and metabolism · 2013Trial
- The plasma proteome identifies expected and novel proteins correlated with micronutrient status in undernourished Nepalese children.The Journal of nutrition · 2013Trial
- Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury.Nutrients · 2013Trial
- A spontaneously immortalized muscle stem cell line (EfMS) from brown-marbled grouper for cell-cultured fish meat production.Communications biology · 2024Article
- Evaluation of the Effectiveness of Active Vitamin D Use in Experimental Rat Lymphedema Model.Medicina (Kaunas, Lithuania) · 2024Article
- Vitamin D Inadequacy and Its Relation to Body Fat and Muscle Mass in Adult Women of Childbearing Age.Nutrients · 2024Article
- Review
- Article
- The outcomes of dexmedetomidine and calcitriol on flap viability.Acta cirurgica brasileira · 2020Article
- Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.Nutrients · 2019Article
- 1,25-Dihydroxyvitamin D Decreases Tertiary Butyl-Hydrogen Peroxide-Induced Oxidative Stress and Increases AMPK/SIRT1 Activation in C2C12 Muscle Cells.Molecules (Basel, Switzerland) · 2019Article
- The Effect of Vitamin D Supplementation on Skeletal Muscle in theSports (Basel, Switzerland) · 2019Article
- Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes.Molecular and cellular biochemistry · 2019Article
- Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study.International journal of chronic obstructive pulmonary disease · 2018Observational
- Vitamin D, a modulator of musculoskeletal health in chronic kidney disease.Journal of cachexia, sarcopenia and muscle · 2017Review
- Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells.Endocrine connections · 2017Article
- Calcitriol promotes survival of experimental random pattern flap via activation of autophagy.American journal of translational research · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Vitamin D is mostly recognized for its regulation of calcium homeostasis in relation to the intestine, kidney, and bone. Although clinical studies have linked vitamin D with increased muscle function and strength, little is known of its underlying molecular mechanism. We recently demonstrated that 1,25-D3 exerts a direct pro-myogenic effect on skeletal muscle cells; this has provoked our investigation of 1,25-D's effect on angiogenesis, a vital process for new capillary development and tissue repair. In this study, we examined the mechanism by which 1,25-D3 modulates key angiogenic growth factors and angiogenic inhibitors. C(2)C(12) myoblasts were incubated with 100 nM 1,25-D3 or placebo for 1, 4 and 10 days. At the end of the respective incubation time, total RNA was isolated for PCR arrays and for qRT-PCR. Total proteins were isolated for Western blots and proteome profiler arrays. The addition of 1,25-D3 to C(2)C(12) myoblasts increased VEGFa and FGF-1: two pro-angiogenic growth factors that promote neo-vascularization and tissue regeneration, and decreased FGF-2 and TIMP-3: two myogenic and/or angiogenic inhibitors. Our previous study demonstrated that 1,25-D3 altered IGF-I/II expression, consistent with the observed changes in VEGFa and FGF-2 expression. These results extend our previous findings and demonstrate the modulation of angiogenesis which may be an additional mechanism by which 1,25-D3 promotes myogenesis. This study supports the mechanistic rationale for assessing the administration of vitamin D and/or vitamin D analogs to treat select muscle disorders and may also provide an alternative solution for therapies that directly manipulate VEGF and FGF's to promote angiogenesis.
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Registered trials
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