ArticleJournal of molecular biology2012
Structural analysis of the quaking homodimerization interface.
Article in Journal of molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- The transcriptional cortical response to daily torpor inLife science alliance · 2026Article
- Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing.eLife · 2026Article
- Diverse roles of quaking in endothelial cell biology.Angiogenesis · 2025Review
- Viroids and Retrozymes: Plant Circular RNAs Capable of Autonomous Replication.Plants (Basel, Switzerland) · 2024Review
- Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes.Journal of structural biology: X · 2024Article
- Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1Molecular cancer · 2024Article
- Quaking regulates circular RNA production in cardiomyocytes.Journal of cell science · 2023Article
- Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).Life science alliance · 2022Article
- QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer.Journal of molecular cell biology · 2021Article
- QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.Nature communications · 2021Article
- The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function.Frontiers in cell and developmental biology · 2021Review
- Stability and flexibility of full-length human oligodendrocytic QKI6.BMC research notes · 2019Article
- Identification of Novel Binding Partners for Transcription Factor Emx2.The protein journal · 2019Article
- Molecular Characterization of the RNA-Binding Protein Quaking-a inFrontiers in physiology · 2018Article
- CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles.Oncogene · 2017Article
- Autogenous cross-regulation ofGenes & development · 2017Article
- RNA-binding Protein Quaking StabilizesThe Journal of biological chemistry · 2017Article
- Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression.Scientific reports · 2016Article
- Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Quaking (QkI) is a prototypical member of the STAR (signal transducer and activator of RNA) protein family, which plays key roles in posttranscriptional gene regulation by controlling mRNA translation, stability and splicing. QkI-5 has been shown to regulate mRNA expression in the central nervous system, but little is known about its roles in other tissues. STAR proteins function as dimers and bind to bipartite RNA sequences; however, the structural and functional roles of homodimerization and heterodimerization are still unclear. Here, we present the crystal structure of the QkI dimerization domain, which adopts a similar stacked helix-turn-helix arrangement as its homologs GLD-1 (germ line development defective-1) and Sam68 (Src-associated protein during mitosis, 68kDa) but differs by an additional helix inserted in the dimer interface. Variability of the dimer interface residues likely ensures selective homodimerization by preventing association with non-cognate STAR family proteins in the cell. Mutations that inhibit dimerization also significantly impair RNA binding in vitro, alter QkI-5 protein levels and impair QkI function in a splicing assay in vivo. Together, our results indicate that a functional Qua1 homodimerization domain is required for QkI-5 function in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.