ReviewRespiratory physiology & neurobiology2013
Carotid chemoreceptor "resetting" revisited.
Review in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Quantitative and Qualitative Changes in Peripheral Chemoreceptor Activity in Preterm Infants.American journal of respiratory and critical care medicine · 2023Trial
- Respiratory plasticity induced by chronic hyperoxia in juvenile and adult rats.Respiratory physiology & neurobiology · 2025Article
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Influence of chronic hypoxia on the hypoxic ventilatory response of juvenile and adult rats.Respiratory physiology & neurobiology · 2023Article
- Effects of Prenatal Cannabinoids Exposure upon Placenta and Development of Respiratory Neural Circuits.Advances in experimental medicine and biology · 2023Review
- Apnoea of Prematurity and Neurodevelopmental Outcomes: Current Understanding and Future Prospects for Research.Frontiers in pediatrics · 2021Review
- Ventilatory and carotid body responses to acute hypoxia in rats exposed to chronic hypoxia during the first and second postnatal weeks.Respiratory physiology & neurobiology · 2020Article
- Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude.The Journal of experimental biology · 2020Article
- Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation.Frontiers in neuroscience · 2019Article
- Oxygen Sensing in Early Life.Lung · 2016Review
- Adaptation to Life in the High Andes: Nocturnal Oxyhemoglobin Saturation in Early Development.Sleep · 2016Article
- Thalamic mediation of hypoxic respiratory depression in lambs.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Cardiorespiratory control and cytokine profile in response to heat stress, hypoxia, and lipopolysaccharide (LPS) exposure during early neonatal period.Physiological reports · 2016Article
- Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells.Respiratory physiology & neurobiology · 2015Article
- Oxygen extremes, inflammation, and neonatal breathing.Respiratory physiology & neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Carotid body (CB) chemoreceptors transduce low arterial O(2) tension into increased action potential activity on the carotid sinus nerves, which contributes to resting ventilatory drive, increased ventilatory drive in response to hypoxia, arousal responses to hypoxia during sleep, upper airway muscle activity, blood pressure control and sympathetic tone. Their sensitivity to O(2) is low in the newborn and increases during the days or weeks after birth to reach adult levels. This postnatal functional maturation of the CB O(2) response has been termed "resetting" and it occurs in every mammalian species studied to date. The O(2) environment appears to play a key role; the fetus develops in a low O(2) environment throughout gestation and initiation of CB "resetting" after birth is modulated by the large increase in arterial oxygen tension occurring at birth. Although numerous studies have reported age-related changes in various components of the O(2) transduction cascade, how the O(2) environment shapes normal CB prenatal development and postnatal "resetting" remains unknown. Viewing CB "resetting" as environment-driven (developmental) phenotypic plasticity raises important mechanistic questions that have received little attention. This review examines what is known (and not known) about mechanisms of CB functional maturation, with a focus on the role of the O(2) environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.