ArticleBehavioural brain research2013
AMPA receptor mediated behavioral plasticity in the isolated rat spinal cord.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Plasticity in Cervical Motor Circuits following Spinal Cord Injury and Rehabilitation.Biology · 2021Review
- Evidence That the Central Nervous System Can Induce a Modification at the Neuromuscular Junction That Contributes to the Maintenance of a Behavioral Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- The Spinal Cord, Not to Be Forgotten: the Final Common Path for Development, Training and Recovery of Motor Function.Perspectives on behavior science · 2018Article
- Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury.Frontiers in neural circuits · 2014Review
- Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury.Frontiers in physiology · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Previous research has demonstrated that the spinal cord is capable of a simple form of instrumental learning. Spinally transected rats that receive shock to a hind leg in an extended position quickly learn to maintain the leg in a flexed position, reducing net shock exposure whenever that leg is flexed. Subjects that receive shock independent of leg position (uncontrollable shock) do not exhibit an increase in flexion duration and later fail to learn when tested with controllable shock (learning deficit). The present study examined the role of the ionotropic glutamate receptor α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in spinal learning. Intrathecal application of the AMPA receptor antagonist CNQX disrupted performance of a spinal instrumental learning in a dose dependent fashion (Experiment 1). CNQX also disrupted the maintenance of the instrumental response (Experiment 2) and blocked the induction of the learning deficit (Experiment 3). Intrathecal application of the agonist AMPA had a non-monotonic effect, producing a slight facilitation of performance at a low dose and disrupting learning at a high concentration (Experiment 4). Within the dose range tested, intrathecal application of AMPA did not have a long-term effect (Experiment 5). The results suggest that AMPA-mediated transmission plays an essential role in both instrumental learning and the induction of the learning deficit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.