ArticleBehavioural brain research2013
Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Proximity in mice induced by an auditory-conditioned stimulus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Identity-stable multi-animal tracking using bidirectional segmentation with object-level memory.bioRxiv : the preprint server for biology · 2025Article
- Mapping the landscape of social behavior.Cell · 2025Article
- Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Therapeutic timing limitations of postnatal darbepoetin in a valproic acid rat model of Autism Spectrum Disorder.PloS one · 2025Article
- Mapping the landscape of social behavior.bioRxiv : the preprint server for biology · 2024Article
- Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Aggression in Group-Housed Male Mice: A Systematic Review.Animals : an open access journal from MDPI · 2022Review
- Transcription factor gene Pea3 regulates erectile function during copulation in mice.PloS one · 2022Article
- Mapping the living mouse brain neural architecture: strain-specific patterns of brain structural and functional connectivity.Brain structure & function · 2021Article
- Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene.Genes, brain, and behavior · 2020Article
- Collective Housing of Mice of Different Age Groups before Maturity Affects Mouse Behavior.Behavioural neurology · 2020Article
- Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder.Nature communications · 2019Article
- Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice.Experimental neurobiology · 2019Article
- Comparing Postnatal Development of Gonadal Hormones and Associated Social Behaviors in Rats, Mice, and Humans.Endocrinology · 2018Review
- Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice.Genes, brain, and behavior · 2017Article
- Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene.Biological psychiatry · 2017Article
- Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.Current topics in behavioral neurosciences · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BALB/cJ and C57BL/6J inbred mouse strains have been proposed as useful models of low and high levels of sociability (tendency to seek social interaction), respectively, based primarily on behaviors of ∼30-day-old mice in the Social Approach Test (SAT). In the SAT, approach and sniffing behaviors of a test mouse toward an unfamiliar stimulus mouse are measured in a novel environment. However, it is unclear whether such results generalize to a familiar environment with a familiar social partner, such as with a littermate in a home cage environment. We hypothesized that C57BL/6J mice would show higher levels of social behaviors than BALB/cJ mice in the home cage environment, particularly at 30 days-of-age. We measured active and passive social behaviors in home cages by pairs of BALB/cJ or C57BL/6J littermates at ages 30, 41, and 69 days. The strains did not differ robustly in their active social behaviors. C57BL/6J mice were more passively social than BALB/cJ mice at 30 days, and C57BL/6J levels of passive social behaviors declined to BALB/cJ levels by 69 days. The differences in passive social behaviors at 30 days-of-age were primarily attributable to differences in huddling. These results indicate that different test conditions (SAT conditions vs. home cage conditions) elicit strain differences in distinct types of behaviors (approach/sniffing vs. huddling behaviors, respectively). Assessment of the more naturalistic social interactions in the familiar home cage environment with a familiar littermate will provide a useful component of a comprehensive assessment of social behaviors in mouse models relevant to autism.
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