ArticleBiological psychiatry2013
Prefrontal cortex modulates desire and dread generated by nucleus accumbens glutamate disruption.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 96 citations in OpenAlex.
- Ketone Supplementation Attenuates Prediction Error Taste Response in Eating Disorders: A Proof-of-Concept Study.The International journal of eating disorders · 2026Trial
- A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2024Article
- Article
- Neuronal Ensembles in the Infralimbic Cortex Dynamically Process Distinct Aspects of Hedonic Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural Mechanisms Mediating Sex Differences in Motivation for Reward: Cognitive Bias, Food, Gambling, and Drugs of Abuse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cerebellar glutamatergic system impacts spontaneous motor recovery by regulating Gria1 expression.NPJ Regenerative medicine · 2022Article
- Aberrant impulse control circuitry in obesity.Molecular psychiatry · 2022Article
- A Subset of Nucleus Accumbens Neurons Receiving Dense and Functional Prelimbic Cortical Input Are Required for Cocaine Seeking.Frontiers in cellular neuroscience · 2022Article
- Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?Neuroscience and biobehavioral reviews · 2021Review
- Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear.Neurobiology of stress · 2021Article
- Incentive motivation: 'wanting' roles of central amygdala circuitry.Behavioural brain research · 2021Review
- Context-Specific Tolerance and Pharmacological Changes in the Infralimbic Cortex-Nucleus Accumbens Shell Pathway Evoked by Ketamine.Neurochemical research · 2021Article
- From Desire to Dread-A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa.Journal of clinical medicine · 2021Review
- Social discounting of pain.Journal of the experimental analysis of behavior · 2020Article
- Activation of Infralimbic to Nucleus Accumbens Shell Pathway Suppresses Conditioned Aversion in Male But Not Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal-directed action: A brief review.Journal of neuroscience research · 2020Review
- Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults.Addiction biology · 2020Article
- Desire or Dread from Nucleus Accumbens Inhibitions: Reversed by Same-Site Optogenetic Excitations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Identifying the representational structure of affect using fMRI.Affective science · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCorticolimbic circuits, including direct projections from prefrontal cortex to nucleus accumbens (NAc), permit top-down control of intense motivations generated by subcortical circuits. In rats, localized disruptions of glutamate signaling within medial shell of NAc generate desire or dread, anatomically organized along a rostrocaudal gradient analogous to a limbic keyboard. At rostral locations in shell, these disruptions generate appetitive eating, but at caudal locations the disruptions generate progressively fearful behaviors (distress vocalizations, escape attempts, and antipredator reactions). Here, we asked whether medial prefrontal cortex can modulate intense motivations generated by subcortical NAc disruptions.
methodsWe used simultaneous microinjections in medial prefrontal cortex regions and in NAc shell to examine whether the desire or dread generated by NAc shell disruptions is modulated by activation/inhibition of three specific regions of prefrontal cortex: medial orbitofrontal cortex, infralimbic cortex (homologous to area 25 or subgenual anterior cingulate in the human), or prelimbic cortex (midventral anterior cingulate).
resultsWe found that activation of medial orbitofrontal cortex biased intense bivalent motivation in an appetitive direction by amplifying generation of eating behavior by middle to caudal NAc disruptions, without altering fear. In contrast, activation of infralimbic prefrontal cortex powerfully and generally suppressed both appetitive eating and fearful behaviors generated by NAc shell disruptions.
conclusionsThese results suggest that corticolimbic projections from discrete prefrontal regions can either bias motivational valence or generally suppress subcortically generated intense motivations of desire or fear.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.