ArticleCell2012
Diabetic β Cells: To Be or Not To Be?
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Zinc accumulation-induced integrated stress response triggers β-cell identity loss.Cell research · 2026Article
- mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic β Cell Function.Frontiers in genetics · 2020Review
- Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.Human molecular genetics · 2019Article
- Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance.International journal of biological macromolecules · 2019Article
- Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review.Frontiers in pharmacology · 2017Review
- DNA methylation directs functional maturation of pancreatic β cells.The Journal of clinical investigation · 2015Article
- Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.Cell metabolism · 2014Article
- Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice.Frontiers in cellular neuroscience · 2014Article
- Article
- VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus.Genes & development · 2013Article
- Review
- Update on the protective molecular pathways improving pancreatic beta-cell dysfunction.Mediators of inflammation · 2013Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
β cell dysfunction with subsequent apoptosis is considered a significant contributor to the development of type 2 diabetes. Emerging data from Talchai et al. suggest β cell dedifferentiation as an alternative mechanism of insulin insufficiency that might be more amenable to intervention in at least a subset of patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.