ReviewCurrent opinion in cell biology2012
Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits.
Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Endothelial dysfunction determines vascular mechanisms of metastatic progression in breast cancer.Discover oncology · 2026Review
- The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells.Bioscience reports · 2023Article
- The Journey of Cancer Cells to the Brain: Challenges and Opportunities.International journal of molecular sciences · 2023Review
- Passage Number of 4T1 Cells Influences the Development of Tumour and the Progression of Metastasis in 4T1 Orthotopic Mice.The Malaysian journal of medical sciences : MJMS · 2022Article
- Quantifying protrusions as tumor-specific biophysical predictors of cancer invasion in in vitro tumor micro-spheroid models.In vitro models · 2022Article
- Collective Cell Migration in a Fibrous Environment: A Hybrid Multiscale Modelling Approach.Frontiers in applied mathematics and statistics · 2021Article
- The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity.American journal of cancer research · 2021Review
- Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)-dependent manner.Oncology letters · 2019Article
- Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates.Scientific reports · 2018Article
- GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.Cancer cell · 2018Article
- Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration.Nature communications · 2017Article
- UBE2J2 promotes hepatocellular carcinoma cell epithelial-mesenchymal transition and invasionOncotarget · 2017Article
- NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway.Oncogenesis · 2016Article
- Article
- The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis.Cell cycle (Georgetown, Tex.) · 2014Review
- Invadopodia and basement membrane invasion in vivo.Cell adhesion & migration · 2014Review
- Regulation of invadopodia by the tumor microenvironment.Cell adhesion & migration · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Metastatic cancer cells produce invasive membrane protrusions called invadopodia and pseudopodia, which play a central role in driving cancer cell dissemination in the body. Malignant cells use these structures to attach to and degrade extracellular matrix proteins, generate force for cell locomotion, and to penetrate the vasculature. Recent work using unique subcellular fractionation methodologies combined with spatial genomic, proteomic, and phosphoproteomic profiling has provided insight into the invadopodiome and pseudopodiome signaling networks that control the protrusion of invasive membranes. Here I highlight how these powerful spatial 'omics' approaches reveal important signatures of metastatic cancer cells and possible new therapeutic targets aimed at treating metastatic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.