ArticleMayo Clinic proceedings2012
Comparison of the effect of the metabolic syndrome and multiple traditional cardiovascular risk factors on vascular function.
Article in Mayo Clinic proceedings, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Predictive value of vascular response to cuff inflation-induced pain in the control arm for adverse cardiovascular events.International journal of cardiology. Heart & vasculature · 2021Article
- Medical management of metabolic and cardiovascular complications after liver transplantation.World journal of gastroenterology · 2020Review
- Peripheral Endothelial Function as a Marker of Systemic Vasodilation in End-stage Liver Disease: Results of a Pilot Study.Transplantation direct · 2020Article
- From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome.Journal of endocrinological investigation · 2018Review
- Relation of Biochemical Parameters with Flow-mediated Dilatation in Patients with Metabolic Syndrome.Chinese medical journal · 2017Article
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.Cardiovascular diabetology · 2016Article
- Postprandial decrease in LDL-cholesterol in men with metabolic syndrome.Open medicine (Warsaw, Poland) · 2015Article
- The impact of long-term changes in metabolic status on cardiovascular biomarkers and microvascular endothelial function in middle-aged men: a 25-year prospective study.Diabetology & metabolic syndrome · 2015Article
- Utility of both carotid intima-media thickness and endothelial function for cardiovascular risk stratification in patients with angina-like symptoms.International journal of cardiology · 2015Observational
- The importance of autophagy in cardioprotection.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2014Review
- Heart disease and stroke statistics--2014 update: a report from the American Heart Association.Circulation · 2014Article
- Endothelial dysfunction over the course of coronary artery disease.European heart journal · 2013Review
- High leukocyte count is associated with peripheral vascular dysfunction in individuals with low cardiovascular risk.Circulation journal : official journal of the Japanese Circulation Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo assess the effect of the metabolic syndrome (MetS) on endothelial function and compare these findings to those in individuals with a similar burden of traditional cardiovascular (CV) risk factors (≥ 3) without MetS. PATIENTS AND
methodsBoth MetS and multiple CV risk factors were identified from 1103 individuals who underwent the evaluation of endothelial function at the Mayo Clinic, in Rochester, Minnesota, from July 1, 2000, through July 31, 2011. Endothelial function was measured using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index [RHI]).
resultsA total of 316 individuals with MetS and 210 with multiple risk factors were assessed. Endothelial dysfunction was more pronounced in the MetS group compared with the multiple risk factor group (mean ± SD natural logarithmic RHI, 0.61 ± 0.25 and 0.68 ± 0.28, respectively; P=.006). Leukocyte count (7.00 ± 1.89 × 10(9)/L vs 6.41 ± 1.76 × 10(9)/L, respectively; P=.001) and high-sensitivity C-reactive protein level (1.78 ± 1.53 mg/L vs 1.48 ± 1.42 mg/L, respectively; P=.01) were higher in the MetS group compared with the multiple risk factor group. After adjustment for covariates and 6 traditional CV risk factors in a multivariate regression model, MetS had a significant and independent influence on natural logarithmic RHI (β=-.11; P=.01).
conclusionThe current study found that individuals with MetS have a higher degree of endothelial dysfunction and inflammation compared with individuals with multiple CV risk factors and may therefore have an increased CV risk beyond the contributions of multiple traditional risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.