ArticleMayo Clinic proceedings2012
Asthma and proinflammatory conditions: a population-based retrospective matched cohort study.
Article in Mayo Clinic proceedings, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Association between OLD and IBD: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Association Between Asthma and All-Cause Mortality and Cardiovascular Disease Morbidity and Mortality: A Meta-Analysis of Cohort Studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis.Clinical and translational gastroenterology · 2018Pooled it
- Pooled it
- Asthma and the risk of cardiovascular diseases and mortality: a meta-analysis of cohort studies.Therapeutic advances in respiratory diseasePooled it
- Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis.Annals of Saudi medicinePooled it
- Association Between Asthma and the Risk of Type 2 Diabetes Mellitus: Results From NHANES 2009-2016 Data.International journal of endocrinology · 2026Article
- Associations of asthma with cardiometabolic diseases and multimorbidity: A cohort study in the UK Biobank.NPJ primary care respiratory medicine · 2025Article
- Association between neighborhood deprivation and type 2 diabetes risks among asthma patients: a nationwide population-based cohort study.Scientific reports · 2025Article
- Association between asthma and type 2 diabetes in a Swedish adult population: a register-based cross-sectional study.Thorax · 2025Article
- Diabetes-inducing effects of bronchial asthma.World journal of diabetes · 2025Article
- Association of Wheezing Requiring Hospitalization Before 2 Years of Age With Autoimmune Diseases During Childhood: A 15-Year Follow-up Study From Birth.Allergy, asthma & immunology research · 2024Article
- Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024Review
- Longitudinal changes in DNA methylation during the onset of islet autoimmunity differentiate between reversion versus progression of islet autoimmunity.Frontiers in immunology · 2024Article
- Understanding the Link Between Adult Asthma and Coronary Artery Disease: A Narrative Review.Cureus · 2023Review
- Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study.BMC medical genomics · 2023Article
- Type 2 Diabetes Mellitus and Asthma: Pathomechanisms of Their Association and Clinical Implications.Cureus · 2023Review
- Article
- Association of weight-adjusted-waist index with asthma prevalence and the age of first asthma onset in United States adults.Frontiers in endocrinology · 2023Article
- Basis of preventive and non-pharmacological interventions in asthma.Frontiers in public health · 2023Review
Corrections and comments
- Commented on by
- Commented on byIn reply.2013
Authors and funding
10 authors.
Funding
Abstract
objectiveTo determine the association between asthma and proinflammatory conditions. PARTICIPANTS AND
methodsThis population-based retrospective matched cohort study enrolled all asthmatic patients among Rochester, Minnesota, residents between January 1, 1964, and December 31, 1983. For each asthmatic patient, 2 age-and sex-matched nonasthmatic individuals were drawn from the same population. The asthmatic and nonasthmatic cohorts were followed forward in the Rochester Epidemiology Project diagnostic index for inflammatory bowel disease (IBD), rheumatoid arthritis (RA), diabetes mellitus (DM), and coronary heart disease (CHD) as outcome events. Data were fitted to Cox proportional hazards models.
resultsWe identified 2392 asthmatic patients and 4784 nonasthmatic controls. Of the asthmatic patients, 1356 (57%) were male, and mean age at asthma onset was 15.1 years. Incidence rates of IBD, RA, DM, and CHD in nonasthmatic controls were 32.8, 175.9, 132.0, and 389.7 per 100,000 person-years, respectively; those for asthmatic patients were 41.4, 227.9, 282.6, and 563.7 per 100,000 person-years, respectively. Asthma was associated with increased risks of DM (hazard ratio, 2.11; 95% confidence interval, 1.43-3.13; P<.001) and CHD (hazard ratio, 1.47; 95% confidence interval, 1.05-2.06; P=.02) but not with increased risks of IBD or RA.
conclusionAlthough asthma is a helper T cell type 2-predominant condition, it may increase the risks of helper T cell type 1-polarized proinflammatory conditions, such as CHD and DM. Physicians who care for asthmatic patients need to address these unrecognized risks in asthmatic patients.
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