Evidence map›Paper›PMID 22980123›Full record

ArticleEpilepsy research2012

Conditional deletion of TrkC does not modify limbic epileptogenesis.

A Soren Leonard, Ram S Puranam, Jeffrey Helgager, Gumei Liu, James O McNamara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A Soren LeonardDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Ram S Puranam
Jeffrey Helgager
Gumei Liu
James O McNamara

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Neurotrophins and EpileptogenesisR01NS056217 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2006 to 2023
$6.7M
Basic Predoctoral Training in NeuroscienceT32GM008441 · NIGMS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 1992 to 2017
$4.4M
A study of epileptogenesis in genetically modified miceF32NS051064 · NINDS · DUKE UNIVERSITY · PI LEONARD, ARTHUR S · 2005 to 2006
$102k
NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM008441NINDS NIH HHS 5R01NS56217NINDS NIH HHS F32 NS051064NINDS NIH HHS F32 NS051064-01NINDS NIH HHS R01 NS056217
6 · The paper itself

Abstract

The neurotrophin receptor, tropomyosin-related kinase B (TrkB), is required for epileptogenesis in the kindling model. The role of a closely related neurotrophin receptor, TrkC, in limbic epileptogenesis is unknown. We examined limbic epileptogenesis in the kindling model in TrkC conditional null mice, using a strategy that previously established a critical role of TrkB. Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice. These findings reinforce the central role of TrkB as the principal neurotrophin receptor involved in limbic epileptogenesis.

Indexed as

AnimalsDisease Models, AnimalEpilepsyGene DeletionIntegrasesKindling, NeurologicLimbic SystemMembrane GlycoproteinsMiceMice, KnockoutProtein-Tyrosine KinasesReceptor, trkBReceptor, trkCRNA, MessengerCre recombinaseIntegrasesMembrane GlycoproteinsNtrk2 protein, mouseProtein-Tyrosine KinasesReceptor, trkBReceptor, trkCRNA, Messenger

Identifiers

PMID22980123
PMCPMC3489989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.