ArticleCNS neuroscience & therapeutics2012
E-selectin deficiency attenuates brain ischemia in mice.
Article in CNS neuroscience & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The expression changes endothelial and fibrinolytic biomarkers in acute ischemic stroke patients with OSA.BMC neurology · 2025Article
- Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord.Scientific reports · 2025Article
- TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli.Cell communication and signaling : CCS · 2024Article
- Higher Serum E-Selectin Levels Associated with Malignant Brain Edema after Endovascular Thrombectomy for Ischemic Stroke: A Pilot Study.Brain sciences · 2023Article
- Inflammatory biomarkers of ischemic stroke.Internal and emergency medicine · 2023Review
- Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench.Aging and disease · 2021Review
- Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies.Frontiers in physiology · 2021Article
- Adhesion of Leukocytes to Cerebral Venules Precedes Neuronal Cell Death and Is Sufficient to Trigger Tissue Damage After Cerebral Ischemia.Frontiers in neurology · 2021Article
- Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds.Frontiers in physiology · 2020Review
- Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke.American journal of physiology. Cell physiology · 2019Review
- The antiaging activity and cerebral protection of rapamycin at micro-doses.CNS neuroscience & therapeutics · 2014Article
- The effects of anakinra on focal cerebral ischemic injury in rats.CNS neuroscience & therapeutics · 2014Article
- Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats.Journal of neuroinflammation · 2014Article
- Relations of serum soluble E-selectin and adiponectin with enlarged perivascular spaces in patients with recent lacunar infarction.CNS neuroscience & therapeutics · 2014Article
- Neuronal and astrocytic interactions modulate brain endothelial properties during metabolic stresses of in vitro cerebral ischemia.Cell communication and signaling : CCS · 2014Article
- Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function.Acta pharmacologica Sinica · 2013Article
- MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke.CNS neuroscience & therapeutics · 2013Article
- Involvement of arterial baroreflex in the protective effect of dietary restriction against stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Comparison of infarct volume and behavioral deficit in Wistar Kyoto and spontaneously hypertensive rat after transient occlusion of the middle cerebral artery.SpringerPlus · 2013Article
- Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles.Progress in neurobiologyReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine whether E-selectin deficiency can attenuate brain ischemia in a mouse model of focal cerebral ischemia.
methodsE-selectin was determined in spontaneously hypertensive rats (SHRs) and stroke-prone spontaneously hypertensive rats (SHR-SPs). E-selectin knockout (Es(-/-) ) mice and wild-type control (WT) mice underwent permanent distal middle cerebral artery occlusion (MCAO). Behavioral analyses were performed followed by the measurement of infarct areas. Myeloperoxidase (MPO) protein was determined by Western blot. IL-6, IL-1β, and TNF-α were detected by ELISA. In situ detection of apoptotic cells was performed by TUNEL staining.
resultsThe brain and serum E-selectin levels were higher in SHR-SPs than in SHRs (P < 0.05) after salt intake. E-selectin deficiency improved neurological function and reduced infarct area in cerebral ischemic mice. MPO and IL-1β were lower in Es(-/-) mice than in WT mice. In addition, the number of apoptotic cells in Es(-/-) mice was significantly less than in WT mice after MCAO.
conclusionsE-selectin deficiency presents protective effect on cerebral ischemia. This protective effect is likely achieved by the inhibition of inflammation and apoptosis.
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